Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

SML3923

Sigma-Aldrich

NU7441

≥98% (HPLC)

Synonym(s):

8-Dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one, NU 7441, NU-7441

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C25H19NO3S
CAS Number:
503468-95-9
Molecular Weight:
413.49
MDL number:
MFCD11983069
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

SMILES string

[s]1c2c(c6c1cccc6)cccc2c3c4[o]c(c[c](c4ccc3)=O)N5CCOCC5

InChI

1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2

InChI key

JAMULYFATHSZJM-UHFFFAOYSA-N

Biochem/physiol Actions

Potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor in vitro and in vivo.
NU7441 is a potent and selective DNA-dependent protein kinase inhibitor (DNA-PK IC50 = 14 nM; IC50 = 1.7 μM/mTOR, 5 μM/PI3Kα, >100 μM/ATM & ATR) that effectively sensitizes cancer cells to the cytotoxic effects of both ionizing radiation and the topoisomerase II inhibitor etoposide in cultures (0.5 μM; SW620 & LoVo cells) and in vivo (10 mg/kg via daily i.p. in mice with human colon cancer SW620 xenografts).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000410886
0000410886
0000303014
0000327998
0000327999

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated
Biochemical Pharmacology, 71(1-2), 13-20 (2005)
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
Cancer research, 66(10), 5354-5362 (2006)
Justin J J Leahy et al.
Bioorganic & medicinal chemistry letters, 14(24), 6083-6087 (2004-11-18)
A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6-, 7- and 8-aryl-substituted chromenone libraries, which were screened as inhibitors of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). These studies resulted in the identification of 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one (NU7441)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service