Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SML2370

Sigma-Aldrich

Dabigatran

Dabigatran

≥95% (HPLC)

Synonym(s):

BIBR-953, N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C25H25N7O3
CAS Number:
211914-51-1
Molecular Weight:
471.51
MDL number:
MFCD09837830
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

0.1 M HCl: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N=C(N)C(C=C1)=CC=C1NCC(N2C)=NC3=C2C=CC(C(N(CCC(O)=O)C4=NC=CC=C4)=O)=C3

InChI

1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)

InChI key

YBSJFWOBGCMAKL-UHFFFAOYSA-N

Biochem/physiol Actions

Dabigatran is a nonpeptide direct thrombin inhibitor. It is an anticoagulant that functions by directly inhibiting both free and fibrin-bound thrombin. Dabigatron has been shown to prevent strokes in those with atrial fibrillation not caused by heart valve issues.
Nonpeptide, direct thrombin inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000228009
0000233720
0000233721
0000179266
0000179265

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Giuseppe Femia et al.
Heart, lung & circulation, 27(7), 798-803 (2017-08-15)
For some patients with atrial fibrillation, direct current cardioversion (DCCV) is one strategy that can be used to establish sinus rhythm but appropriate anticoagulation is mandatory to prevent thromboembolic events. Historically, patients were anticoagulated with warfarin with bridging with unfractionated
Damon Klebe et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(9), 3135-3149 (2017-02-06)
We aim to determine if direct thrombin inhibition by dabigatran will improve long-term brain morphological and neurofunctional outcomes and if potential therapeutic effects are dependent upon reduced PAR-1 stimulation and consequent mTOR activation. Germinal matrix haemorrhage was induced by stereotaxically
Hao Zhang et al.
Frontiers in cellular and infection microbiology, 11, 677902-677902 (2021-08-03)
Patients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported. However, the role of circulating NETs in the progression and thrombotic tendency of sepsis-induced lung injury
Wolfgang G Eisert et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(10), 1885-1889 (2010-07-31)
Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response. Peak
Gut microbial I?-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Edwinson, et al.
Nature microbiology, 7, 680-694 (2022)
1 Review This action will navigate to reviews.

Questions

  1. Hello, How to reconstitute dabigatran? Thank you

    1 answer

    1. This product can be solubilized in 0.1M HCl at > 2.0 mg/ml. The exact solubility of this product will be listed on the lot-specific Certificate of Analysis.

      Please navigate to the DOCUMENTATION section of the Product Detail Page to access a sample or lot specific Certificate under ‘Certificate of Analysis’:
      https://www.sigmaaldrich.com/product/sigma/sml2370#product-documentation

      Helpful?

Reviews

Active Filters

  1. Geneva
    • Review 1
    • Votes 0
    1 out of 5 stars.

    Too large bootle for 5 mg bottle

    Placing a 5 mg powder in a large glass bottle is really inconvenient. The power cannot be taken out at all.

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for your review.
      SML2370 is supplied in a large enough vial for the product to be reconstituted in it. This allows the full amount to be reconstituted without losing powder while transferring. Please do not transfer powder out of the vial before reconstitution.
      We encourage customers who experience problems with our products to contact us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service