SAB4700731

Monoclonal Anti-HLA-DR antibody produced in mouse

clone L243, purified immunoglobulin, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: L243, monoclonal
• form: buffered aqueous solution
• species reactivity: nonhuman primates, human, dog
• concentration: 1 mg/mL
• technique(s): FUNC: suitable; flow cytometry: suitable; immunoblotting: suitable; immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• isotype: IgG2a
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... HLA-DRA(3122)

Description

General description

Human leukocyte antigen (HLA)-DR is a member of HLA class II molecules. It is encoded by the gene mapped to human chromosome 6.(21} HLA class II molecules are highly expressed on B-Iymphocytes, but is also found at minimal levels on T-Iymphocytes, macrophages, thymus epithelial cells and selected cells of various body tissues. HLA-DR consists of a non-polymorphic α chain gene and up to three distinct highly polymorphic β chain genes.

The mouse monoclonal antibody L243 recognizes specifically HLA-DR molecules, both peptide-loaded and empty.

Immunogen

Human B lymphocytes

Application

Monoclonal Anti-HLA-DR antibody produced in mouse has been used in double immunofluorescent staining.

Biochem/physiol Actions

Human leukocyte antigen (HLA)-DR activates a T-cell receptor by presenting antigenic peptides derived from extracellular proteins thus, stimulating an immune response against the antigen.{22] Mutation in the gene increases the risk of susceptibility to inflammatory bowel disease (IBD), Crohn′s disease and ulcerative colitis. Overexpression of monocytic (HLA)-DR has been observed in schizophrenic patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable