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251755

Sigma-Aldrich

Osmium tetroxide solution

4 wt. % in H2O

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About This Item

Linear Formula:
OsO4
CAS Number:
20816-12-0
Molecular Weight:
254.23
MDL number:
MFCD00011150
UNSPSC Code:
12352303
PubChem Substance ID:
329752782
NACRES:
NA.21

vapor pressure

1.23 psi ( 20 °C)
3.55 psi ( 55 °C)

Quality Level

100

form

liquid

reaction suitability

reagent type: oxidant

concentration

3.5-4.5% (OsO4)
4 wt. % in H2O

density

1.0 g/mL at 20 °C
1.04 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

O=[Os](=O)(=O)=O

InChI

1S/4O.Os

InChI key

VUVGYHUDAICLFK-UHFFFAOYSA-N

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General description

OsO4 (4wt% in H2O) is widely employed in organic synthesis especially for hydroxylation reactions. Additionally, it is also involved in the oxidative cleavage of alkenes.

Application


  • In situ X-ray-assisted electron microscopy staining for large biological samples.: This study explores the use of osmium tetroxide solution for X-ray-assisted electron microscopy staining, enhancing the visualization of large biological samples (Ströh et al., 2022).

  • Application of the electron microscope to the cytochemical peroxidase reaction in salamander leukocytes.: The use of osmium tetroxide solution in electron microscopy enhances the cytochemical analysis of peroxidase reactions in salamander leukocytes, providing clear and detailed images (MITSUI, 1960).


Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Asymmetric induction in the reaction of osmium tetroxide with olefins.
Hentges SG and Barry Sharpless K.
Journal of the American Chemical Society, 102(12), 4263-4265 (1980)
On stereochemistry of osmium tetroxide oxidation of allylic alcohol systems: empirical rule.
Cha JK, et al.
Tetrahedron Letters, 24(37), 3943-3946 (1983)
Kinetics of Oxidation of Some Fluoroquinolones by Hexacyanoferrate (III) in Alkaline Medium.
Diab N, et al.
International Journal of Chemistry (Canadian Center of Science and Education), 34(2), 1388-1388 (2013)
Yukihiko Sugita et al.
The Journal of general virology, 92(Pt 11), 2485-2493 (2011-07-29)
Negatively stained influenza virions sometimes show irregular morphology and are often referred to as pleomorphic. However, this irregular morphology has not been visualized when ultrathin-section transmission and scanning electron microscopies are used. This study focused on the effects of ultracentrifugation
Carsten Købler et al.
Analytical and bioanalytical chemistry, 406(16), 3863-3873 (2014-01-23)
Ultrastructural characterisation is important for understanding carbon nanotube (CNT) toxicity and how the CNTs interact with cells and tissues. The standard method for this involves using transmission electron microscopy (TEM). However, in particular, the sample preparation, using a microtome to
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