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416789

Sigma-Aldrich

1,1,1-Trifluoro-3-phenyl-2-propanone

96%

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About This Item

Linear Formula:
C6H5CH2COCF3
CAS Number:
Molecular Weight:
188.15
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

96%

form

liquid

refractive index

n20/D 1.444 (lit.)

bp

51-52 °C/2 mmHg (lit.)

density

1.22 g/mL at 25 °C (lit.)

SMILES string

FC(F)(F)C(=O)Cc1ccccc1

InChI

1S/C9H7F3O/c10-9(11,12)8(13)6-7-4-2-1-3-5-7/h1-5H,6H2

InChI key

IAJKTOIWQHTZOS-UHFFFAOYSA-N

General description

1,1,1-Trifluoro-3-phenyl-2-propanone is a trifluoromethyl ketone. Its in vitro neuroprotective potency against low K(+)-induced apoptosis in cerebellar granule neurons (CGNs) by different pathways has been reported.

Pictograms

Flame

Signal Word

Warning

Hazard Statements

Hazard Classifications

Flam. Liq. 3

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

91.4 °F - closed cup

Flash Point(C)

33 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Katsuyoshi Sunaga et al.
In vivo (Athens, Greece), 16(2), 97-101 (2002-06-21)
We previously reported that two trifluoromethyl ketones, 3,3,3-trifluoro-1-phenyl-1,2-propanedione (TF1) and 1,1,1-trifluoro-3-phenyl-2-propanone (TF2), have neuroprotective effects against low K(+)-induced apoptosis in cerebellar granule neurons (CGNs) exposed at 12-13 days in vitro (DIV). On the other hand, these compounds showed weak neuroprotective

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