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14960

Sigma-Aldrich

Bis(2-hydroxypropyl)amine

≥98.0% (T)

Synonym(s):

1,1′-Iminodi-2-propanol, Diisopropanolamine

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About This Item

Linear Formula:
NH[CH2CH(OH)CH3]2
CAS Number:
110-97-4
Molecular Weight:
133.19
Beilstein:
605363
EC Number:
203-820-9
MDL number:
MFCD00004531
UNSPSC Code:
12352100
PubChem Substance ID:
57647230
NACRES:
NA.22

Assay

≥98.0% (T)

form

solid

impurities

≤1% water

bp

249-250 °C/745 mmHg (lit.)

mp

42-45 °C (lit.)

solubility

H2O: miscible
alcohol: miscible

density

1.004 g/mL at 25 °C (lit.)

SMILES string

CC(O)CNCC(C)O

InChI

1S/C6H15NO2/c1-5(8)3-7-4-6(2)9/h5-9H,3-4H2,1-2H3

InChI key

LVTYICIALWPMFW-UHFFFAOYSA-N

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Application

Bis(2-hydroxypropyl)amine (Diisopropanolamine) was used to study its effects upon choline uptake and phospholipid synthesis in Chinese hamster ovary (CHO) cells.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

275.0 °F - closed cup

Flash Point(C)

135 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Two cases of contact dermatitis due to diisopropanolamine.
Yoshihiro Umebayashi
The Journal of dermatology, 32(2), 145-146 (2005-05-24)
W T Stott et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(2), 761-766 (2007-11-09)
Aminoalcohols differ in mammalian toxicity at least in part based upon their ability to alter the metabolism of phospholipids and to cause depletion of the essential nutrient choline in animals. This study examined the incorporation of diisopropanolamine (DIPA) into phospholipids
K A Johnson et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 45(10), 1838-1845 (2007-05-18)
The repeated dose oral and dermal toxicity of diisopropanolamine (DIPA) was evaluated in rats and compared to the reported toxicity of the related secondary alcohol amine, diethanolamine (DEA). Fischer 344/DuCrl rats were given up to 750 mg/kg/day by dermal application
L M Gieg et al.
Canadian journal of microbiology, 45(5), 377-388 (1999-08-14)
Diisopropanolamine (DIPA) is a "sweetening agent" used to remove hydrogen sulfide from sour natural gas, and it is a contaminant at some sour gas treatment facilities in western Canada. To investigate the biodegradation of this alkanolamine, 14C-DIPA was used in
Y Konishi et al.
IARC scientific publications, (105)(105), 318-321 (1991-01-01)
The carcinogenic activity of endogenously synthesized N-nitroso-bis(2-hydroxy-propyl)amine (NDHPA) was investigated in male Wistar rats administered bis(2-hydroxypropyl)amine (DHPA), mixed into a powdered diet at a concentration of 1%, and NaNO2 dissolved in distilled water at concentrations of 0.15% and 0.3%, for
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