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SML2705

Sigma-Aldrich

TP-008

≥98% (HPLC)

Synonym(s):

1-[2-(5-Chloro-2-fluorophenyl)-5-methyl-4-pyridinyl]-1,2-dihydro-2-oxo-3H -imidazo[4,5-c ]pyridine-3-acetamide, 2-(1-(2-(5-Chloro-2-fluorophenyl)-5-methylpyridin-4-yl)-2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)acetamide

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About This Item

Empirical Formula (Hill Notation):
C20H15ClFN5O2
CAS Number:
Molecular Weight:
411.82
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

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ZRB1407MABS1132MABC1036
clone

5F3.1, monoclonal

clone

recombinant monoclonal

clone

8F3.1, monoclonal

clone

2F3.1, monoclonal

biological source

mouse

biological source

rabbit

biological source

mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified immunoglobulin

species reactivity

human

species reactivity

human, mouse

species reactivity

mouse, rat

species reactivity

human

UniProt accession no.

Q9NQW6

UniProt accession no.

Q9NQW6

UniProt accession no.

O76039

UniProt accession no.

Q15375

Biochem/physiol Actions

SGC Frankfurt Pharma donated probe. TP-008 is a cell penetrant, potent and selective ALK4/5 ((activin-like kinase 4/5) dual inhibitor that potently inhibits SMAD2/3 phosphorylation in C2C12 cells. TP-008 exhibits significant cardiac toxicity in mice. It is compound 18 in BMCL 2016 paper.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Haixia Wang et al.
    Bioorganic & medicinal chemistry letters, 26(17), 4334-4339 (2016-07-28)
    Using SBDD, a series of 4-amino-7-azaindoles were discovered as a novel class of Alk5 inhibitors that are potent in both Alk5 enzymatic and cellular assays. Subsequently a ring cyclization strategy was utilized to improve ADME properties leading to the discovery

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