Monoclonal Anti-Digoxin (mouse IgG1 isotype) is derived from the hybridoma DI-22 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with digoxin conjugated to keyhole limpet hemocyanin (KLH).
Immunogen
immunized with Digoxin
Application
Monoclonal Anti-Digoxin antibody produced in mouse has been used in:
enzyme linked immunosorbent assay (ELISA)
dot blot
flow cytometry
immunofluorescence
DNA hybridization
in-situ hybridization (ISH)
Biochem/physiol Actions
Digoxin is an uncharged glycoside which is given to humans with congestive heart failure. It enhances the force of myocardial contraction. Anti-digoxin antibodies can be used to reverse the effects of digoxin.
Unlike other oral inotrope, digoxin does not promote mortality. It inhibits sodium potassium ATPase membrane pump.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
High-affinity monoclonal antibodies to the cardiac glycoside, digoxin.
M M Hunter et al.
Journal of immunology (Baltimore, Md. : 1950), 129(3), 1165-1172 (1982-09-01)
Digoxin
Eichhorn EJ and Gheorghiade M
Progress in Cardiovascular Diseases, 44(4), 251-266 (2002)
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