R0654

Reveromycin A

solid, suitable for cell culture, BioReagent

• Empirical Formula (Hill Notation): C₃₆H₅₂O₁₁
• CAS Number: 134615-37-5
• Molecular Weight: 660.79
• MDL number: MFCD00912537
• UNSPSC Code: 12352207
• PubChem Substance ID: 24899342
• NACRES: NA.76

Properties

• product name: Reveromycin A, solid
• biological source: Streptomyces sp.
• Quality Level: 200
• form: solid
• mol wt: 660.79 g/mol
• packaging: pkg of 100 μg
• color: tan
• solubility: DMF: soluble; DMSO: soluble; ethanol: soluble; ethyl acetate: soluble; methanol: soluble; soluble
• antibiotic activity spectrum: fungi
• Mode of action: protein synthesis | interferes
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [H][C@]1(C\C=C(C)\C=C\[C@H](O)[C@@H](C)\C=C\C(O)=O)O[C@]2(CC[C@@H]1C)CC[C@@](CCCC)(OC(=O)CCC(O)=O)[C@@]([H])(O2)\C=C\C(C)=C\C(O)=O
• InChI: 1S/C36H52O11/c1-6-7-19-35(47-34(44)17-16-32(40)41)21-22-36(46-30(35)14-10-25(3)23-33(42)43)20-18-27(5)29(45-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29+,30-,35+,36-/m0/s1
• InChI key: ZESGNAJSBDILTB-OXVOKJAASA-N

Description

Biochem/physiol Actions

It is an epidermal growth factor (EGF) and eukaryotic cell growth inhibitor.

Reveromycin A is a polyketide antibiotic from Streptomyces sp. Epidermal growth factor (EGF) inhibitor; apoptosis inducer; G₁ phase cell cycle inhibitor having antiproliferative behavior against human cell lines KB and K562 as well as antifungal activity.

Analysis Note

Avoid acidic conditions.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves