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N0758

Sigma-Aldrich

Naphthol AS-D chloroacetate

esterase substrate, fluorogenic, ≥98% (TLC), powder

Synonym(s):

3-Hydroxy-2-naphthoic-o-toluidide chloroacetate

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About This Item

Empirical Formula (Hill Notation):
C20H16ClNO3
CAS Number:
35245-26-2
Molecular Weight:
353.80
EC Number:
252-463-5
MDL number:
MFCD00042714
UNSPSC Code:
12352204
PubChem Substance ID:
24897441
NACRES:
NA.83
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Product Name

Naphthol AS-D chloroacetate, esterase substrate

Quality Level

200

Assay

≥98% (TLC)

form

powder

solubility

acetone: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cc1ccccc1NC(=O)c2cc3ccccc3cc2OC(=O)CCl

InChI

1S/C20H16ClNO3/c1-13-6-2-5-9-17(13)22-20(24)16-10-14-7-3-4-8-15(14)11-18(16)25-19(23)12-21/h2-11H,12H2,1H3,(H,22,24)

InChI key

FMVKYSCWHDVMGO-UHFFFAOYSA-N

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Application

Naphthol AS-D chloroacetate has been in a substrate solution for naphthol-AS-D-chloroacetate-esterase (CIAE) staining.[1][2]
Naphthol AS-D chloroacetate has been used as a component of the substrate solution for naphthol-AS-D-chloroacetate-esterase (CIAE) staining to detect:
  • the paraffin-embedded kidney tissues[2]
  • polymorphonuclear (PMN) cells[1]
  • endometrial tissues[3]
  • neutrophils from mice small intestine[4][5]

Substrates

Substrate for histochemical localization of esterases

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000417238
0000417237
0000417223
0000417237
0000417223

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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
Maekawa H, et al.
Cell Reports, 29(5), 1261-1273 (2019)
Hafez Sadeghi et al.
PloS one, 17(1), e0263409-e0263409 (2022-01-29)
The assessment of polymorphonuclear leukocyte (PMN) proportions (%) of endometrial samples is the hallmark for subclinical endometritis (SCE) diagnosis. Yet, a non-biased, automated diagnostic method for assessing PMN% in endometrial cytology slides has not been validated so far. We aimed
Ivonne Maciel Arciniega-Martínez et al.
Journal of neuroimmunology, 362, 577764-577764 (2021-11-26)
Muscarinic-acetylcholine-receptors (mAChRs) modulate intestinal homeostasis, but their role in inflammation is unclear; thus, this issue was the focus of this study. BALB/c mice were treated for 7 days with muscarine (mAChR/agonist), atropine (mAChR/antagonist) or saline. Small-intestine samples were collected for histology
Antonis Ioannou et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(3), G283-G292 (2012-10-30)
Ischemia-reperfusion (IR) injury causes a vigorous immune response that is amplified by complement activation, leading to local and remote tissue damage. Using MRL/lpr mice, which are known to experience accelerated tissue damage after mesenteric IR injury, we sought to evaluate
Martin Zweifel et al.
Immunology and cell biology, 83(6), 587-595 (2005-11-04)
Mast cells (MC) can undergo significant changes in number and phenotype; these alterations result in the differential expression of growth factors and cytokines. Kit ligand (KL; stem cell factor) is produced by mesenchymal cells, and in the liver by biliary
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