D8008
7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
≥95%
Synonym(s):
DEDA
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About This Item
Empirical Formula (Hill Notation):
C22H40O2
CAS Number:
Molecular Weight:
336.55
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
Recommended Products
biological source
synthetic (organic)
Assay
≥95%
form
liquid
storage temp.
−20°C
SMILES string
CCCCCCCCCCC\C=C/C(C)(C)\C=C/CCCC(O)=O
InChI
1S/C22H40O2/c1-4-5-6-7-8-9-10-11-12-13-16-19-22(2,3)20-17-14-15-18-21(23)24/h16-17,19-20H,4-15,18H2,1-3H3,(H,23,24)/b19-16-,20-17-
InChI key
AGKRHAILCPYNFH-DUQSFWPASA-N
Gene Information
human ... ADORA2A(135) , ADORA2B(136)
Biochem/physiol Actions
Inhibitor of phospholipase A2 and lipoxygenase. Inhibits endogenous synthesis of leukotrienes.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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C S Ramesha et al.
Analytical biochemistry, 192(1), 173-180 (1991-01-01)
a simple gas chromatographic method for the assay of phospholipase A2 (PLA2) has been described in which arachidonic acid released from endogenous phospholipid pools is measured following its extraction and derivatization to pentafluorobenzyl esters. Using this assay, PLA2 activities in
D G Johns et al.
The American journal of physiology, 275(5 Pt 2), H1592-H1598 (1998-11-14)
Ceramide is a novel second messenger generated by hydrolysis of membrane sphingomyelin by a neutral sphingomyelinase (nSMase). Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been shown to increase intracellular ceramide through phospholipase A2 (PLA2)-dependent activation of nSMase. TNF-alpha has
S Huang et al.
Kidney international, 55(5), 1740-1749 (1999-05-07)
We have studied interleukin-1 (IL-1)-stimulated signals and gene expression in mesangial cells (MCs) to identify molecular mechanisms of MC activation, a process characteristic of glomerular inflammation. The JNK1 pathway has been implicated in cell fate decisions, and IL-1 stimulates the
Espen Mariussen et al.
Toxicology and applied pharmacology, 179(3), 137-144 (2002-03-22)
Polychlorinated biphenyls (PCBs) are widespread persistent environmental contaminants that display a complex spectrum of toxicological properties, including neurotoxicity. The present study investigates the effects of the PCB mixtures Aroclor 1242 (A1242) and Aroclor 1254 (A1254), and the PCB congeners 126
Jannike M Andersen et al.
Neurochemical research, 28(2), 319-326 (2003-03-01)
In this paper we show that exposure of a rat brain synaptosome fraction to the amyloid beta peptide fragment betaA(25-35), but not the inverted peptide betaA(35-25), stimulated production of reactive oxygen species (ROS) in a concentration- and time-dependent manner. The
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