A6376
N-Acetyl-L-tryptophan
≥99% (TLC), suitable for ligand binding assays
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About This Item
Empirical Formula (Hill Notation):
C13H14N2O3
CAS Number:
Molecular Weight:
246.26
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Pricing and availability is not currently available.
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Product Name
N-Acetyl-L-tryptophan,
Assay
≥99% (TLC)
Quality Level
form
powder
technique(s)
ligand binding assay: suitable
color
white to off-white
storage temp.
2-8°C
SMILES string
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
InChI
1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1
InChI key
DZTHIGRZJZPRDV-LBPRGKRZSA-N
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Related Categories
Biochem/physiol Actions
N-Acetyl-L-tryptophan (NAT, Ac-Trp-OH) is used a substance P NK1 tachykinin receptor antagonist. N-Acetyl-L-tryptophan is also used as a competitive inhibitor to identify, differentiate and characterized tryptophanase(s).
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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James J Donkin et al.
Journal of neurotrauma, 28(2), 217-224 (2010-12-24)
Previous studies have demonstrated that the compound N-acetyl-L-tryptophan (NAT) reduces brain edema and improves functional outcome following traumatic brain injury (TBI). In this study we examined whether this effect was mediated via the neurokinin-1 receptor, and whether there was an
New tryptophanase inhibitors: towards prevention of bacterial biofilm formation.
Scherzer R, Gdalevsky GY, et al.
Journal of Enzyme Inhibition, 24, 350-355 (2009)
M Lehnig et al.
Free radical research, 41(5), 523-535 (2007-04-25)
Tryptophan and melatonin are nitrated by peroxynitrite; tryptophan residues in proteins are susceptible to attack by reactive nitrogen species. Nitrated tryptophan might therefore be used as a biomarker for the involvement of reactive species derived from nitrogen oxide in a
Renée J Turner et al.
Brain research, 1393, 84-90 (2011-04-07)
Previous studies have suggested that substance P (SP) plays a critical role in the development of brain oedema and functional deficits following traumatic brain injury and that SP receptor antagonism may improve outcome. No studies have described such a role
Liqiong Fang et al.
Journal of chromatography. A, 1218(41), 7316-7324 (2011-09-10)
N-acetyltryptophan (NAT) has long been used as a stabilizer in some protein solutions, such as human serum albumin, to prevent oxidative protein degradation. However, the fate of NAT has not been discussed in literature. Two NAT degradation products have been
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