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Sigma-Aldrich

Kollicoat® IR

Synonym(s):

Macrogol-poly(vinyl alcohol) graft-copolymer, Polyvinyl alcohol-polyethylene glycol graft-copolymer

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About This Item

CAS Number:
96734-39-3
UNSPSC Code:
12162002
NACRES:
NA.25
Pricing and availability is not currently available.

impurities

ethylene glycol, complies (meets the requirements of Macrogol Polyvinylalcohol Grafted Copolymer Ph Eur Ed. 7)
≤1 ppm ethylene oxide
≤10 ppm dioxan
≤100 ppm vinyl acetate
≤15000 ppm acetic acid
≤20 ppm heavy metals

Quality Level

200

ign. residue

≤2%

loss

≤5% loss on drying

pH

5.0-8.0 (20% in H2O)

viscosity

50-250 mPa.s, 20 %(23 °C, Brookfield RVT) (SP.2, 100RPM)

ester number

10‑70 mg KOH/g

Application

Kollicoat IR is used in the pharmaceutical industry as a binder, pellets, and particulate matter. This research grade product is intended for use in R&D and development only.

Legal Information

Kollicoat is a registered trademark of BASF SE

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL2360
BCCK3276
BCCJ5782
BCCG4258
BCCF7577

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Susanne Muschert et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 72(1), 130-137 (2009-01-17)
The aim of this study was to better understand the underlying drug release mechanisms from aqueous ethylcellulose-coated pellets containing different types of drugs and starter cores. Theophylline, paracetamol, metoprolol succinate, diltiazem HCl and metoprolol tartrate were used as model drugs
Kyung Jin Son et al.
ACS applied materials & interfaces, 3(2), 573-581 (2011-02-05)
In this study, we describe the use of organized mesoporous titanium oxide (TiO(2)) films as three-dimensional templates for protein microarrays with enhanced protein loading capacity and detection sensitivity. Multilayered mesoporous TiO(2) films with high porosity and good connectivity were synthesized
Sandra Guns et al.
Pharmaceutical research, 28(3), 673-682 (2010-11-26)
To investigate the effect of the manufacturing method (spray-drying or hot-melt extrusion) on the kinetic miscibility of miconazole and the graft copolymer poly(ethyleneglycol-g-vinylalcohol). The effect of heat pre-treatment of solutions used for spray-drying and the use of spray-dried copolymer as
Pan Liu et al.
Journal of pharmaceutical sciences, 101(8), 2811-2820 (2012-05-23)
The objective of this study was to investigate the drug release mechanism and in vivo performance of Tanshinone IIA sustained-release pellets, coated with blends of polyvinyl acetate (PVAc) and poly(vinyl alcohol)-poly(ethylene glycol) (PVA-PEG) graft copolymer. A formulation screening study showed

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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