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11161

Sigma-Aldrich

Sodium (R)-β-hydroxyisobutyrate

≥96.0%

Synonym(s):

(R)-β-Hydroxyisobutyric acid sodium salt, (R)-3-Hydroxy-2-methylpropionic acid sodium salt, R-HIBA, R-β-HIBA-Na, Sodium (R)-3-hydroxy-2-methylpropionate

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About This Item

Empirical Formula (Hill Notation):
C4H7NaO3
CAS Number:
1228078-57-6
Molecular Weight:
126.09
MDL number:
MFCD17215934
UNSPSC Code:
12352209
PubChem Substance ID:
329749318
NACRES:
NA.25

Assay

≥96.0% (GC)
≥96.0%

optical purity

enantiomeric excess: ≥98.0%

composition

sodium, 17.5-19.0%

storage temp.

2-8°C

SMILES string

[Na+].C[C@H](CO)C([O-])=O

InChI

1S/C4H8O3.Na/c1-3(2-5)4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1/t3-;/m1./s1

InChI key

RBJZIQZDAZLXEK-AENDTGMFSA-M

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Application

3-Hydroxyisobutyrate (HIBA) may be used to study the distribution, characterization and kinetics of enzymes involved in branched chain amino acid metabolism such as 3-hydroxyisobutyrate dehydrogenase (EC: 1.1.1.31) and 3-hydroxyisobutyryl-CoA hydrolase (EC: 3.1.2.4). (R)-β-hydroxyisobutyrate may be used in stereospecific studies.

Biochem/physiol Actions

Increased urinary concentrations of 3-hydroxyisobutyric acid are a biochemical hallmark of metabolic disease 3-hydroxyisobutyric aciduria.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Neuropathology of 3-hydroxyisobutyric aciduria, an autopsy case report.
Xianyuan Song et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 36(4), 483-486 (2009-08-05)
Jörn Oliver Sass et al.
Journal of inherited metabolic disease, 35(3), 437-442 (2011-08-25)
3-hydroxyisobutyric aciduria is an organic aciduria with a poorly understood biochemical basis. It has previously been assumed that deficiency of 3-hydroxyisobutyrate dehydrogenase (HIBADH) in the valine catabolic pathway is the underlying enzyme defect, but more recent evidence makes it likely
Tianran Yao et al.
Applied biochemistry and biotechnology, 160(3), 694-703 (2009-06-12)
The MmsB gene product from Bacillus cereus ATCC14579 exhibits 3-hydroxypropionate dehydrogenase activity. It encodes the 32-kDa enzyme protein composed of 292 amino acids. Recombinant 3-hydroxyisobutyrate dehydrogenase (3-HIBADH) was purified 100-fold from cell extract by ammonium sulfate fractionation and column chromatography.
Ronald J A Wanders et al.
Journal of inherited metabolic disease, 35(1), 5-12 (2010-11-26)
Valine is one of the three branched-chain amino acids which undergoes oxidation within mitochondria. In this paper, we describe the current state of knowledge with respect to the enzymology of the valine oxidation pathway and the different disorders affecting oxidation.
Ference J Loupatty et al.
American journal of human genetics, 80(1), 195-199 (2006-12-13)
Only a single patient with 3-hydroxyisobutyryl-CoA hydrolase deficiency has been described in the literature, and the molecular basis of this inborn error of valine catabolism has remained unknown until now. Here, we present a second patient with 3-hydroxyisobutyryl-CoA hydrolase deficiency
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