Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

375810

Sigma-Aldrich

Periodic acid

ACS reagent, 99%

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
H5IO6
CAS Number:
10450-60-9
Molecular Weight:
227.94
EC Number:
233-937-0
MDL number:
MFCD00011344
UNSPSC Code:
12352106
PubChem Substance ID:
329755660
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

Assay

99%
99.0-101.0% (ACS specification)

form

powder or crystals

reaction suitability

reaction type: C-H Activation
reagent type: catalyst
reagent type: oxidant

impurities

≤0.01% insolubles
≤0.01% other halogens

ign. residue

≤0.01%

mp

122 °C (lit.)

solubility

water: soluble

anion traces

sulfate (SO42-): ≤0.01%

cation traces

Fe: ≤0.003%
heavy metals: ≤0.005%

application(s)

histology

SMILES string

OI(O)(O)(O)(O)=O

InChI

1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)

InChI key

TWLXDPFBEPBAQB-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Periodic acid is an inorganic acid commonly used as an oxidizing agent. Periodic acid oxidation is one of the steps in the periodate-resorcinol assay, used in the determination of sialic acid. Periodic acid reacts with 1,2 glycol linkage of carbohydrates to form aldehydes which can be stained by Schiff′s reagent. Therefore periodic-acid-Schiff′s reagent (PAS) is used in histochemistry to determine carbohydrates in tissue sections.

Application

Periodic acid may be used in the following reactions:
  • Oxidation of alcohols to ketones and aldehydes.
  • Oxidation hydroxylamine derivatives.
  • Oxidation of arenes to quinones.
  • Deprotection of the dithio- and oxathio-derivatives.
  • Oxidative degradation of epoxidized natural rubber (ENR).
  • Oxidation of urazoles and bis-urazoles to triazolinediones.
  • Oxidative cleavage of glucosazone.

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral

Target Organs

Thyroid

Storage Class Code

5.1A - Strongly oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The Action of Periodic Acid on Glucose Phenylosazone.
Chargaff E and Magasanik B.
Journal of the American Chemical Society, 69(6), 1459-1461 (1947)
Further Observations Concerning the Periodic Acid Oxidation of Hydroxylamine Derivatives1.
Emery TF and. Neilands JB.
The Journal of Organic Chemistry, 27(3), 1075-1077 (1962)
The first report on the catalytic oxidation of urazoles to their corresponding triazolinediones via in situ catalytic generation of Br+ using periodic acid or oxone/KBr system.
Zolfigol MA, et al.
J. Mol. Catal. A: Chem., 270(1), 219-224 (2007)
The sialic acids. XI. A periodate-resorcinol method for the quantitative estimation of free sialic acids and their glycosides.
G W Jourdian et al.
The Journal of biological chemistry, 246(2), 430-435 (1971-01-25)
Deblocking of dithioacetals and oxathioacetals using periodic acid under mild nonaqueous conditions.
Shi XX, et al.
Tetrahedron Letters, 37(25), 4331-4334 (1996)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service