78697

Methyl methanesulfonate

certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

• Synonym(s): Methanesulfonic acid methyl ester
• Linear Formula: CH₃SO₃CH₃
• CAS Number: 66-27-3
• Molecular Weight: 110.13
• Beilstein: 1098586
• EC Number: 200-625-0
• MDL number: MFCD00007557
• UNSPSC Code: 41116107
• PubChem Substance ID: 329768176
• NACRES: NA.24

Properties

• grade: certified reference material; TraceCERT^®
• Quality Level: 300
• product line: TraceCERT^®
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.414 (lit.)
• bp: 202-203 °C (lit.)
• density: 1.3 g/mL at 25 °C (lit.)
• application(s): environmental; pharmaceutical
• format: neat
• storage temp.: 2-8°C
• SMILES string: COS(C)(=O)=O
• InChI: 1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3
• InChI key: MBABOKRGFJTBAE-UHFFFAOYSA-N

Description

General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com.

Methyl methanesulfonate belongs to the group of alkyl sulfonate esters, termed as potential genotoxic impurities (GTIs).

Application

Methyl methanesulfonate may be used as certified reference material for the quantification of the analyte in pharmaceutical formulations using gas chromatography coupled to triple quadrupole mass spectrometry.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Principle

DNA adduct; adds methyl groups to DNA at 7-guanine preferentially, but also 3-adenine and 3-guanine.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H301,H315,H317,H319,H340,H351,H361fd,H373,H411
• Precautionary Statements: P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Inhalation
• Target Organs: Lungs
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): 219.2 °F - closed cup
• Flash Point(C): 104 °C - closed cup