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54752

Sigma-Aldrich

Methyl 4-hydroxybenzoate

tested according to Ph. Eur.

Synonym(s):

Methylis parahydroxybenzoas, p-Hydroxybenzoic acid methyl ester, Methyl paraben, NIPAGIN

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About This Item

Linear Formula:
HOC6H4CO2CH3
CAS Number:
Molecular Weight:
152.15
Beilstein:
509801
EC Number:
MDL number:
UNSPSC Code:
51452201
PubChem Substance ID:
NACRES:
NA.25

Agency

USP/NF
tested according to Ph. Eur.

Assay

99.7%

form

solid

mp

125-128 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

COC(=O)c1ccc(O)cc1

InChI

1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

InChI key

LXCFILQKKLGQFO-UHFFFAOYSA-N

Gene Information

rat ... Ar(24208)

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Application


  • Single crystal, Hirshfeld surface and theoretical analysis of methyl 4-hydroxybenzoate, a common cosmetic, drug and food preservative-Experiment versus theory.: This research provides a detailed analysis of the crystal structure of Methyl 4-hydroxybenzoate, offering insights into its stability and effectiveness as a preservative in various applications, including cosmetics and pharmaceuticals (Sharfalddin et al., 2020).

  • Photostabilization of papaverine hydrochloride solutions.: This article explores the role of Methyl 4-hydroxybenzoate in enhancing the photostability of papaverine hydrochloride solutions, crucial for maintaining the efficacy of this pharmaceutical under exposure to light (Piotrowska et al., 2010).

Pictograms

Environment

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

334.4 °F

Flash Point(C)

168 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Gabriela Oliveira et al.
International journal of pharmaceutics, 435(1), 38-49 (2012-05-29)
Simple topical formulations which include volatile components, such as gels or sprays, are appealing from a cosmetic perspective. However, complex formulation effects may result from the use of volatile excipients in topical formulations, particularly when applied at clinically relevant doses
Ismail I Hewala et al.
Talanta, 88, 623-630 (2012-01-24)
Simple methods for HPTLC peak purity assessment and identification of the HPTLC peaks were presented. The spectrodensitograms - selected at different time intervals across the elution time of the HPTLC peak - were extracted and digital algorithms for manipulating the
Kyung-Jin Min et al.
Aging cell, 7(2), 199-206 (2008-01-29)
Reduced insulin/insulin-like growth factor (IGF) signaling may be a natural way for the reduction of dietary nutrients to extend lifespan. While evidence challenging this hypothesis is accumulating with Caenorhabditis elegans, for Drosophila melanogaster it is still thought that insulin/IGF and
M G Soni et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 40(10), 1335-1373 (2002-10-22)
Methyl paraben (CAS No. 99-76-3) is a methyl ester of p-hydroxybenzoic acid. It is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics for over 50 years. Methyl paraben is readily and completely absorbed through
K Kannathasan et al.
Acta tropica, 120(1-2), 115-118 (2011-07-19)
The vector-borne diseases caused by mosquitoes are one of the major health problems in many countries especially in tropical and sub-tropical countries. The resistance of mosquitoes to synthetic chemicals and environmental toxicity created by the chemicals raised the demand for

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