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H6377

Sigma-Aldrich

1-Hydroxypyridine-2-thione zinc salt

≥95%

Synonym(s):

Mercaptopyridine N-oxide zinc salt, Pyrithione

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About This Item

Empirical Formula (Hill Notation):
C10H8N2O2S2Zn
CAS Number:
13463-41-7
Molecular Weight:
317.70
EC Number:
236-671-3
MDL number:
MFCD00067336
UNSPSC Code:
12352100
PubChem Substance ID:
57654263
NACRES:
NA.22

Quality Level

100

Assay

≥95%

SMILES string

O1N2C=CC=CC2=[S][Zn]13ON4C=CC=CC4=[S]3

InChI

1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2

InChI key

OTPSWLRZXRHDNX-UHFFFAOYSA-L

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Application


  • Antimicrobial nanocoatings: The compound 1-Hydroxypyridine-2-thione zinc salt was evaluated for its efficacy in antimicrobial nanocoatings, showcasing its role in enhancing the performance of such coatings used in healthcare and industrial environments to prevent microbial contamination (Molling et al., 2014).

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - STOT RE 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW9769
MKCT8891
MKCQ6554
MKCL4181
SLBL1836V

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J R Schwartz et al.
The British journal of dermatology, 165 Suppl 2, 18-23 (2011-09-23)
Pathogenesis of dandruff/seborrhoeic dermatitis (D/SD) involves Malassezia yeasts, leading to the most widely accepted treatment strategy of topical application of antifungal agents, usually from rinse-off shampoos. The scalp spatial distribution of Malassezia must be mirrored by the distribution of the
K J Mills et al.
The British journal of dermatology, 166 Suppl 2, 33-40 (2012-06-15)
Dandruff/seborrhoeic dermatitis is a common scalp condition that is characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect tissue level events that are poorly understood at the molecular level. The purpose of this work was: (i) to compare
M Tailler et al.
Oncogene, 31(30), 3536-3546 (2011-11-23)
Despite recent progress in the treatment of acute myeloid leukemia (AML), the prognosis of this rather heterogeneous disease remains poor and novel chemotherapeutics that specifically target leukemic cells must be developed. To address this need at the preclinical level, we
Tomohiro M Oyama et al.
Chemosphere, 87(11), 1316-1322 (2012-02-24)
Zinc pyrithione is used as an antifouling agent. However, the environmental impacts of zinc pyrithione have recently been of concern. Zinc induces diverse actions during oxidative stress; therefore, we examined the effect of zinc pyrithione on rat thymocytes suffering from
Kathy Kerr et al.
Acta dermato-venereologica, 91(4), 404-408 (2011-02-22)
Dandruff and seborrhoeic dermatitis are accompanied by bothersome itch. We have established a novel non-invasive methodology to sample histamine levels in the stratum corneum in order to facilitate an understanding of pruritogenesis in this condition. Histamine levels were assessed in
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