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924490

Sigma-Aldrich

Hyaluronic acid methacrylate

Low Viscosity, Low Endotoxin, 0.2 um sterile filtered, 0.2 μm, sterile-filtered

Synonym(s):

HAMA, Hyaluronan, Hyaluronic acid, MeHA

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About This Item

Linear Formula:
(NaC20H28NO15)n
UNSPSC Code:
12352106
NACRES:
NA.23

Quality Level

description

Validation : HNMR at 40°C

sterility

sterile-filtered

form

(Solid chunks, fibers or powder)

impurities

≤10 CFU/g Bioburden (Fungal)
≤10 CFU/g Bioburden (Total Aerobic)
100 EU/g Endotoxin

color

white to pale yellow

particle size

0.2 μm

storage temp.

2-8°C

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Application

Hyaluronic acid (HA) is a linear polysaccharide of alternating D-glucuronic acid and N-acetyl-D-glucosamine found primarily in connective tissues. HA based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug deliery applications. The methacrylate functionalized hyaluronic acid is photo-crosslinkable, and can be used to generate crosslinked hydrogels.

Packaging

1EA = 500 mg of lyophilized material in glass bottle.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Photocrosslinkable Hyaluronan-Gelatin Hydrogels for Two-Step Bioprinting
Skardal, et al.
Tissue Engineering: Part A, 16 (8) (2010)
Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels.
Duan, et al.
Acta Biomaterialia, 9, 7640-7650 (2018)
Influence of Three-Dimensional Hyaluronic Acid Microenvironments on Mesenchymal Stem Cell Chondrogenesis
Chung and Burdick
Tissue Engineering: Part A, 15(2) (2009)
Micromolding of shape-controlled, harvestable cell-laden hydrogels.
Yeh, et al.
Biomaterials, 27, 5391-5398 (2007)
Judy Yeh et al.
Biomaterials, 27(31), 5391-5398 (2006-07-11)
Encapsulation of mammalian cells within hydrogels has great utility for a variety of applications ranging from tissue engineering to cell-based assays. In this work, we present a technique to encapsulate live cells in three-dimensional (3D) microscale hydrogels (microgels) of controlled

Articles

Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.

Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.

Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.

Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.

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