Skip to Content
Merck
All Photos(1)

Documents

162965

Sigma-Aldrich

2-(2-Chloroethoxy)ethanol

99%

Synonym(s):

Diethylene glycol monochlorohydrin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
ClCH2CH2OCH2CH2OH
CAS Number:
628-89-7
Molecular Weight:
124.57
Beilstein:
506015
EC Number:
211-059-9
MDL number:
MFCD00002870
UNSPSC Code:
12352100
PubChem Substance ID:
24850014
NACRES:
NA.22

Assay

99%

form

liquid

refractive index

n20/D 1.452 (lit.)

bp

79-81 °C/5 mmHg (lit.)

density

1.18 g/mL at 25 °C (lit.)

SMILES string

OCCOCCCl

InChI

1S/C4H9ClO2/c5-1-3-7-4-2-6/h6H,1-4H2

InChI key

LECMBPWEOVZHKN-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

2-(2-Chloroethoxy)ethanol is a chloroalkoxy alcohol commonly used as an organic building block in the synthesis of various pharmaceutical compounds.

Application

2-(2-Chloroethoxy)ethanol was used in the synthesis of o-nitrophenylbromoacetaldehyde bis-2-(2-chloroethoxy)-ethyl acetal, quetiapine (an antipsychotic drug) and 2-(2-azidoethoxy)ethanol.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H315,H318,H335

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

194.0 °F - closed cup

Flash Point(C)

90 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Abdelreheem Abdelfatah Saddik et al.
Journal of materials chemistry. B, 8(43), 9961-9970 (2020-10-14)
The discovery of crown ethers and their unique interactions with ions make them play a key role in supramolecular chemistry. In this study, we have developed a new type of amphiphilic crown ether (DB18C6, DB24C8)-conjugated phenylalanine dipeptides for the gelation
GC method for quantitative determination of residual 2-(2-chloroethoxy) ethanol (CEE) and N-methyl-2-pyrrolidinone (NMP) in quetiapine.
Elzbieta U Stolarczyk et al.
Acta poloniae pharmaceutica, 64(2), 187-189 (2007-08-02)
One-Pot Synthesis of Well-Defined Amphiphilic and Adaptative Block Copolymers via Versatile Combination of ?Click? Chemistry and ATRP.
Mespouille L, et al.
Macromolecular Rapid Communications, 28(22), 2151-2158 (2007)
G C Ellis-Davies et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(1), 187-191 (1994-01-04)
The synthesis and properties of a caged calcium are described. The compound is an ortho-nitrophenyl derivative of EGTA. It is synthesized in 10 steps and with 24% overall yield. The photosensitive chelator, nitrophenyl-EGTA, has a Kd value for Ca2+ of
Yohann Catel et al.
Dental materials : official publication of the Academy of Dental Materials, 37(2), 351-358 (2020-12-29)
To evaluate high refractive index methacrylates as diluents for the formulation of radiopaque esthetic bulk-fill composites. 2-(4-Cumylphenoxy)ethyl methacrylate 1, 2-(2-phenylphenoxy)ethyl methacrylate 2 and 2-[2-(2-phenylphenoxy)ethoxy]ethyl methacrylate 3 were synthesized and characterized by 1H NMR spectroscopy. The reactivity of each monomer was

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service