1612652
USP
Simethicone
United States Pharmacopeia (USP) Reference Standard
Synonym(s):
α-(Trimethylsilyl)-ω-methylpoly[oxy(dimethylsilylene)] mixture with silicon dioxide, Antifoam A, Antifoam AF
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About This Item
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grade
pharmaceutical primary standard
API family
simethicone
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
[Si](O[Si](C)(C)C)(OC)(C)C.[Si](=O)=O
InChI
1S/C6H18O2Si2.O2Si/c1-7-10(5,6)8-9(2,3)4;1-3-2/h1-6H3;
InChI key
AMTWCFIAVKBGOD-UHFFFAOYSA-N
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Simethicone comprises a combination of linear siloxane polymers that are fully methylated and consist of repeating units represented by the formula [–(CH3)2SiO–]n. The polymer is further stabilized using trimethylsiloxy end-blocking units denoted by the formula [(CH3)3SiO–], along with silicon dioxide. [1]
Simethicone comprises a combination of linear siloxane polymers that are fully methylated and consist of repeating units represented by the formula [–(CH3)2SiO–]n. The polymer is further stabilized using trimethylsiloxy end-blocking units denoted by the formula [(CH3)3SiO–], along with silicon dioxide. [1]
Application
Simethicone USP reference standard suitable for use in specified USP compendial tests and assays.
Also used to prepare standard solutions for impurity analysis in Simethicone using the IR technique according to the United States Pharmacopeia (USP) monograph. [1]
Also used to prepare standard solutions for impurity analysis in Simethicone using the IR technique according to the United States Pharmacopeia (USP) monograph. [1]
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
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Product No.
Description
Pricing
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Suriya Keeratichananont et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 93(8), 892-897 (2010-08-20)
Simethicone improves endoscopic visibility and diagnostic accuracy during colonoscopy and capsule endoscopy. Nevertheless, there have been limited data on its usefulness in esophagogastroduodenoscopy (EGD). To evaluate the effectiveness of simethicone on enhancing endoscopic visibility in patients undergoing EGD. 121 patients
Peng Zhao et al.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 26(9), 1130-1133 (2012-10-13)
To review the registration and technical data for breast implants. Recent literature concerning registration for breast implants was reviewed and analyzed. The aspects on registration for breast implants are complicated. The major aspects include providing technical data, establishing develop standard
Krystyna Mojsiewicz-Pieńkowska
Journal of pharmaceutical and biomedical analysis, 58, 200-207 (2011-10-04)
The pharmaceutical industry is one of the more important sectors for the use of polydimethylsiloxanes (PDMS), which belong to the organosilicon polymers. In drugs for internal use, they are used as an active pharmaceutical ingredient (API) called dimeticone or simeticone.
Liucheng Wu et al.
Scandinavian journal of gastroenterology, 46(2), 227-235 (2010-10-28)
The value of supplemental use of Simethicone in endoscopy including capsule endoscopy (CE), colonoscopy and esophagogastroduodenoscopy is not addressed and is controversial. A systematic review and meta-analysis of randomized controlled studies on the use of Simethicone for endoscopy were carried
A Gallo et al.
Minerva medica, 102(2), 133-139 (2011-04-13)
Management of functional dyspepsia is still controversial. Different controlled trials reported a superiority of prokinetics, H2-receptor antagonists and proton-pump inhibitors over placebo; nevertheless, symptomatic improvement after therapy is often incomplete and some of these drugs possess serious side effects. The
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