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SML3329

Sigma-Aldrich

Decursinol Angelate

≥98% (HPLC)

Synonym(s):

(2Z)​-2-​Methyl-2-​butenoic acid (7S)​-​7,​8-​dihydro-​8,​8-​dimethyl-​2-​oxo-​2H,​6H-​benzo[1,​2-​b:5,​4-​b′]​dipyran-​7-​yl ester, Acutilobin

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About This Item

Empirical Formula (Hill Notation):
C19H20O5
CAS Number:
130848-06-5
Molecular Weight:
328.36
MDL number:
MFCD06796687
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Decursinol Angelate is a pyranocoumarin isolated from medical plant Angelica gigas that exhibits potent anti-inflammatory properties. Decursinol Angelate appears to suppress type 17 helper T (Th17) cell responses in dextran sodium sulfate-induced colitis model. Decursinol Angelate reduces the production of NF-κB and COX-2 induced proinflammatory cytokine levels on TPA induced mice ear edema.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Salman Ul Islam et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-01)
Inflammation is considered the root cause of various inflammatory diseases, including cancers. Decursinol angelate (DA), a pyranocoumarin compound obtained from the roots of Angelica gigas, has been reported to exhibit potent anti-inflammatory effects. In this study, the anti-inflammatory effects of
Bikash Thapa et al.
Biomolecules & therapeutics, 27(5), 466-473 (2019-03-29)
Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an anti-inflammatory property, the bioactive compounds of the herbal plant and the effect on T cell responses
Sukkum Ngullie Chang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 132, 110699-110699 (2019-07-28)
Decursinol angelate (DA) is a pyranocoumarin purified from the roots of Angelica gigas. Here, we synthesized DA and determined its anti-inflammatory potential on TPA-induced mice ear inflammation. First, we evaluated the non-toxic behaviour of DA on HaCaT cells. Additionally, we

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