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Key Documents

SML3062

Sigma-Aldrich

BSJ-04-122-R

≥98% (HPLC)

Synonym(s):

N-(2-((5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)phenyl)propionamide

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About This Item

Empirical Formula (Hill Notation):
C15H14ClN5O
CAS Number:
Molecular Weight:
315.76
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CNC2=NC=NC(NC3=CC=CC=C3NC(CC)=O)=C21

Biochem/physiol Actions

BSJ-04-122-R is a reversible control for a potent and selective covalent inhibitor of MKK4 and MKK7 BSJ-04-122. BSJ-04-122-R des not inhibit JNK phosphorylation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jie Jiang et al.
Cell chemical biology, 27(12), 1553-1560 (2020-09-12)
MKK4/7 are kinases that phosphorylate JNKs and regulate the MAPK signaling pathway. Their overexpression has been associated with tumorigenesis and aggressiveness in cancers such as breast, prostate, non-small cell lung, and pediatric leukemia, making them a potential target for inhibitor

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