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Key Documents

SMB01045

Sigma-Aldrich

Isoliquiritin

≥90% (LC/MS-ELSD)

Synonym(s):

4-beta-D-glucopyranosyloxy-2′,4′-dihydroxy-trans-chalcone, Isoliquiritoside

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About This Item

Empirical Formula (Hill Notation):
C21H22O9
CAS Number:
Molecular Weight:
418.39
MDL number:
UNSPSC Code:
12352205
NACRES:
NA.25

biological source

plant

Assay

≥90% (LC/MS-ELSD)

form

solid

mol wt

418.39

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

InChI

1S/C21H22O9/c22-10-17-18(26)19(27)20(28)21(30-17)29-13-5-1-11(2-6-13)3-8-15(24)14-7-4-12(23)9-16(14)25/h1-9,17-23,25-28H,10H2/b8-3+/t17-,18-,19+,20-,21-/m1/s1

InChI key

YNWXJFQOCHMPCK-LXGDFETPSA-N

General description

Isoliquiritin, also known as Isoliquiritoside, is a flavonoid belongs to the class of dihydrochalcones commonly available from Glycyrrhiza Sp. plants. This plant metabolite exhibits various biological activities, including antioxidant, antifungal, anti-HIV, anticancer properties.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Isoliquiritin triggers apoptotic cell death by increasing the levels of p53 and p21 in A549 non-small cell lung cancer cells while also inhibiting the p53-dependent pathway and revealing interactions with Akt activities. Futher, Isoliquiritin has demonstrated neuroprotective activity against oxidative stress and has the capability to restrain the growth of microbial pathogens.

Features and Benefits

  • High quality compound suitable for multiple research applications
  • Compatible with HPLC and mass spectrometry techniques

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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