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Key Documents

P1742

Sigma-Aldrich

Prealbumin from human plasma

lyophilized powder

Synonym(s):

Thyroxine binding prealbumin, Transthyretin

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human plasma

Quality Level

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

technique(s)

immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable

solubility

H2O: soluble 1 mg/mL

ε (extinction coefficient)

13.5 at 280 nm at 1%

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... TTR(7276)

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General description

Human prealbumin is a product of chromosome 18. It is a serum protein, synthesized primarily in the liver. It is a tetrameric protein with a molecular weight of 55 kDa. Human prealbumin is composed of four identical non-covalently bound monomers of 127 amino acid residues arranged with tetrahedral symmetry.

Application

Human prealbumin was used to study reduced transthyretin expression in sera of lung cancer.
Prealbumin from human plasma has been used as a positive control in immunoprecipitation as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.

Biochem/physiol Actions

Human prealbumin has been observed in carcinoid tumors.
Prealbumin levels are indictors of malnutrition and may be modulated during inflammation. It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis. Low levels of prealbumin poses high risk to heart failure (HF).

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing sodium phosphate and NaCl

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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David Adams et al.
Presse medicale (Paris, France : 1983), 41(9 Pt 1), 793-806 (2012-02-22)
The treatment of familial amyloid polyneuropathies (FAP) is complex and requires a neurological and cardiological multidisciplinary coverage. It includes specific treatments to control the progression of the systemic amyloidogenesis, the symptomatic treatment of the peripheral and autonomic neuropathy (digestive, urinary
Gen Sobue
Rinsho shinkeigaku = Clinical neurology, 43(11), 769-774 (2004-05-22)
A nationwide study of CMT and FAP has been performed. In FAP TTR Met30 families with late onset, neuropathy showed male preponderance, low penetrance, little relationship to endemic foci, sensorimotor symptoms beginning distally in the lower extremities with disturbance of
J P Hegmann
Behavior genetics, 9(3), 165-175 (1979-05-01)
Behavioral and physiological scores from 697 mice sampled from lines at various times during their response to bidirectional selection for divergent caudal nerve conduction velocity suggest broad-reaching behavioral effects of the gene differences among lines. Sciatic nerve conduction velocity differences
K Tashima et al.
Journal of the neurological sciences, 171(1), 19-23 (1999-11-24)
Since 1990, liver transplantation for familial amyloidotic polyneuropathy (FAP) has been carried out world-wide, and the outcome of the procedure seems to be promising. FAP is inherited systemic disease caused by mutated transthyretin. The most common cause is the valine
Minori Kodaira et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 18(1), 10-18 (2011-01-26)
The process of deterioration of peripheral nerve function in familial amyloid polyneuropathy (FAP) with amyloidogenic transthyretin (ATTR) Val30Met has not been systematically evaluated hitherto. We performed nerve conduction studies in 69 patients with FAP with ATTR Val30Met from one of

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