M3781

6α-Methylprednisolone 21-hemisuccinate sodium salt

lyophilized powder

• Synonym(s): 6α-Methylprednisolone sodium succinate, MPSL, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate
• Linear Formula: C₂₆H₃₃O₈Na
• CAS Number: 2375-03-3
• Molecular Weight: 496.53
• EC Number: 219-156-8
• MDL number: MFCD00152612
• UNSPSC Code: 51111800
• PubChem Substance ID: 24896873
• NACRES: NA.77

Properties

• biological source: synthetic
• sterility: non-sterile
• Assay: ≥98.00% (TLC)
• form: lyophilized powder
• technique(s): toxicology assay: suitable
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14
• InChI: 1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1
• InChI key: FQISKWAFAHGMGT-SGJOWKDISA-M
• Gene Information: human ... NR3C1(2908)

Description

Application

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Physical form

Lyophilized containing ~5% phosphate buffer salts.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H351,H360
• Precautionary Statements: P201 - P308 + P313
• Hazard Classifications: Carc. 2 - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves