H1640
12(S)-Hydroxy-(5Z,8E,10E)-heptadecatrienoic acid
≥93% (HPLC), ethanol solution
Synonym(s):
12(S)-HHT
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About This Item
Empirical Formula (Hill Notation):
C17H28O3
CAS Number:
Molecular Weight:
280.40
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.25
Pricing and availability is not currently available.
biological source
synthetic (organic)
Quality Level
Assay
≥93% (HPLC)
form
ethanol solution
functional group
carboxylic acid
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCC[C@H](O)\C=C\C=C\C\C=C/CCCC(O)=O
InChI
1S/C17H28O3/c1-2-3-10-13-16(18)14-11-8-6-4-5-7-9-12-15-17(19)20/h5-8,11,14,16,18H,2-4,9-10,12-13,15H2,1H3,(H,19,20)/b7-5-,8-6+,14-11+/t16-/m0/s1
InChI key
KUKJHGXXZWHSBG-WBGSEQOASA-N
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Ana M Vecino et al.
Platelets, 13(7), 415-418 (2002-12-19)
Platelets of patients with uremia develop a defective platelet function and have a decreased production of thromboxane B2 (TxB2). Activated platelets generate thromboxane from free arachidonate that is previously released from the membrane phospholipids (PLs) by phospholipases. Phospholipase A2 (PLA2)
Pontus K A Forsell et al.
Biochemical pharmacology, 71(1-2), 144-155 (2005-11-18)
Polychlorinated biphenyls (PCBs) are stable compounds commonly found in nature as environmental pollutants. PCBs can affect the endocrine function of hormones such as steroid-hormones. Also, PCBs are known to be inducers of arachidonic acid release in various cells. We report
C E Espada et al.
Prostaglandins, leukotrienes, and essential fatty acids, 77(1), 21-28 (2007-07-10)
We investigated the effects of certain dietary polyunsaturated fatty acids (PUFAs) and related eicosanoids on the growth and metastasis formation of a murine mammary gland adenocarcinoma. Salvia hispanica (ChO) and Carthamus tinctorius (SaO) vegetable oil sources of omega-3 and -6
H John et al.
Chemistry and physics of lipids, 95(2), 181-188 (2001-07-19)
It is shown that 12-(S)-hydroxy-(5Z, 8E, 10E)-heptadecatrienoic acid (5-cis-HHT)--a physiological metabolite of arachidonic acid--is acid-catalyzed converted into a less polar substance with its maximum UV-absorption at (1)max=232 nm and a molar absorptivity of about epsilon=26600 +/- 200 M(-1)cm(-1). Using a
Xiuling Li et al.
Archives of biochemistry and biophysics, 467(1), 20-30 (2007-09-21)
Both 12-hydroxyheptadecatrienoic acid (12-HHT) and thromboxane A2 (TXA2) are products derived from prostaglandin H2 (PGH2) catalyzed by thromboxane synthase. Whether or not they exhibit similar actions remains to be determined. While TXA2-induced activation of extracellular signal-regulated kinases (ERKs) has been
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