GW21255B
Anti-Exportin T antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Exportin (tRNA)
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About This Item
Recommended Products
biological source
chicken
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21255B
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... XPOT(11260)
General description
XPOT (exportin T) is a tRNA nuclear export receptor found in vertebrates. This protein shuttles between the cytoplasm and nucleus. It belongs to the importin-β family, and has a distant relation to Los1p protein found in yeast.
Application
Anti-Exportin T antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Exportin-T acts as a specific mediator of tRNA export. Exportin-T is a RanGTP-binding, importin β-related factor with predominantly nuclear localization that shuttles rapidly between nucleus and cytoplasm. It interacts with nuclear pore complexes as well. Exportin-t binds tRNA directly and with high affinity. It is responsible for majority of tRNA export in cells and plays an essential role in the transport of tRNA. It is associated with intracellular tRNA trafficking and is in turn associated with discrete changes in the composition of cellular cytoplasmic multi-protein complexes containing tRNA.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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U Kutay et al.
Molecular cell, 1(3), 359-369 (1998-07-14)
In eukaryotes, tRNAs are synthesized in the nucleus and after several maturation steps exported to the cytoplasm. Here, we identify exportin-t as a specific mediator of tRNA export. It is a RanGTP-binding, importin beta-related factor with predominantly nuclear localization. It
G J Arts et al.
The EMBO journal, 17(24), 7430-7441 (1998-12-19)
Exportin-t (Xpo-t) is a vertebrate nuclear export receptor for tRNAs that binds tRNA cooperatively with GTP-loaded Ran. Xpo-t antibodies are shown to efficiently block tRNA export from Xenopus oocyte nuclei suggesting that it is responsible for at least the majority
C Kruse et al.
The Biochemical journal, 346 Pt 1, 107-115 (2000-02-05)
Vigilin is a ubiquitous multi heterogeneous nuclear ribonucleoprotein (hnRNP) K homologous (KH)-domain protein. Here we demonstrate that purified recombinant human vigilin binds tRNA molecules with high affinity, although with limited specificity. Nuclear microinjection experiments revealed for the first time that
1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.
Takuji Suzuki et al.
Biomedical research (Tokyo, Japan), 27(2), 89-92 (2006-05-19)
The active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3 (DVD), is a potent inducer of cell differentiation and inhibits proliferation of cells such as human promyelocytic leukemia HL-60 cells. In the present study, we examined the effects of DVD on the
G J Arts et al.
Current biology : CB, 8(6), 305-314 (1998-03-25)
Transport of macromolecules between the nucleus and cytoplasm of eukaryotic cells is mediated by nuclear import and export receptors. The receptors identified to date are members of a family of Ran GTPase-binding proteins whose founding member is importin-beta. Interaction between
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