The product is freely soluble in water (~50 mg/mL).
C4520
Cephalothin sodium salt
Synonym(s):
7-(2-Thienylacetamido)cephalosporanic acid sodium salt, Cephalotin sodium salt
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C16H15N2NaO6S2
CAS Number:
Molecular Weight:
418.42
Beilstein:
4120706
EC Number:
MDL number:
UNSPSC Code:
51282506
PubChem Substance ID:
NACRES:
NA.85
Pricing and availability is not currently available.
Recommended Products
form
crystalline powder
Quality Level
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[Na+].CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C([O-])=O
InChI
1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1
InChI key
VUFGUVLLDPOSBC-XRZFDKQNSA-M
Looking for similar products? Visit Product Comparison Guide
General description
Chemical structure: ß-lactam
Application
Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics[1], strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics[2], and for immunology studies in relation to antibiotics.[3] It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.
Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.
Mode of Resistance: Production of cephalosporinase will inactivate the product.
Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.
Mode of Resistance: Production of cephalosporinase will inactivate the product.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
S Mobashery et al.
The Journal of biological chemistry, 261(17), 7879-7887 (1986-06-15)
Two novel C10-(dipeptidyl)cephalosporin esters (3-(beta-chloro-L-alanyl-beta-chloro-L-alanyloxymethyl)-7 beta-(2-thienylacetamido)-3-cephem-4-carboxylic acid (7) and sodium 3-(L-alanyl-L-alanyloxymethyl)-7 beta-(2-thienylacetamido)-3-cephem-4-carboxylate, toluene-sulfonic acid salt (18] were synthesized, and their reactions with Escherichia coli TEM beta-lactamase were examined. Kinetic parameters determined for the enzymatic reactions of 7 (Km = 0.32
Studies on the immune response to penicillin and cephalothin in humans. I. Optimal conditions for titration of hemagglutinating penicillin and cephalothin antibodies.
P Spath et al.
Journal of immunology (Baltimore, Md. : 1950), 107(3), 854-859 (1971-09-01)
J V Desiderio et al.
The Journal of infectious diseases, 148(3), 563-570 (1983-09-01)
Multilamellar liposomes (lipid bilayer vesicles) composed of phosphatidylcholine, cholesterol, and phosphatidylserine (molar ratio, 6:3:1) were produced and then made to entrap an aqueous solution of cephalothin. Resident murine peritoneal macrophages were shown to be capable of interiorizing the liposome-antibiotic complex;
Andreza Conti-Patara et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 22(4), 409-418 (2012-06-27)
To evaluate the changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal-directed hemodynamic optimization in the ICU and their relation to outcome. Prospective observational study. ICU of a veterinary university medical center. Thirty dogs
Smriti Sharma et al.
Journal of molecular modeling, 18(2), 481-492 (2011-05-05)
β-Lactamases are bacterial enzymes that act as a bacterial defense system against β-lactam antibiotics. β-Lactamase cleaves the β-lactam ring of the antibiotic by a two step mechanism involving acylation and deacylation steps. Although class C β-lactamases have been investigated extensively
-
What is the solubility of Cephalothin sodium salt product C4520?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
