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A6969

Sigma-Aldrich

L-Arginine monohydrochloride

98.5-101.0%, suitable for cell culture, not synthetic, meets EP, JP, USP testing specifications

Synonym(s):

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
Molecular Weight:
210.66
Beilstein:
3631658
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

product name

L-Arginine monohydrochloride, not synthetic, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

Assay

98.5-101.0%

form

powder

optical activity

[α]20/D 22.1 to 22.9°, c = 8 in 6 M HCl

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

226-230 °C

solubility

water: 100 mg/mL, clear, colorless

density

1.42 g/cm3 at 20 °C

anion traces

chloride (Cl-): 16.58-17.00%
sulfate (SO42-): ≤0.020%

cation traces

As: ≤1 ppm
Fe: ≤10 ppm
NH4+: ≤0.02%
heavy metals: ≤10 ppm

application(s)

pharmaceutical (small molecule)

functional group

(Guanidine)
amine
carboxylic acid

storage temp.

room temp

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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General description

L-arginine monohydrochloride is the hydrochloride salt form of L-arginine, an essential amino acid that plays a crucial role in several biological processes. It is commonly used in biology and biochemistry research as a cell culture supplement to support the growth and maintenance of various cell types.

Application

L-Arginine monohydrochloride has been used in mouse pancreas perfusion experiments. It has also been used as a component of SILAC medium.

Biochem/physiol Actions

L-Arginine is a dibasic, semi-essential amino acid. It acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins.
Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Features and Benefits

  • Suitable for Cell Culture and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nina C Hubner et al.
Methods (San Diego, Calif.), 53(4), 453-459 (2010-12-28)
Large-scale proteomic screens are increasingly employed for placing genes into specific pathways. Therefore generic methods providing a physiological context for protein-protein interaction studies are of great interest. In recent years many protein-protein interactions have been determined by affinity purification followed
The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice
Anne Orgaard
Diabetologia, 60(9), 1731-1739 (2017)
Lorenzo Galluzzi K
Cell-wide Metabolic Alterations Associated with Malignancy (2014)
J. P. Felix D'Mello
Amino Acids in Human Nutrition and Health (2012)
Élie Lambert et al.
Molecular & cellular proteomics : MCP, 19(5), 808-827 (2020-03-04)
HNF4α is a nuclear receptor produced as 12 isoforms from two promoters by alternative splicing. To characterize the transcriptional capacities of all 12 HNF4α isoforms, stable lines expressing each isoform were generated. The entire transcriptome associated with each isoform was

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