PHR1390

Lansoprazole

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Lansoprazole, 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl] methyl] sulfinyl]-1H-benzimidazole, LAN
• Empirical Formula (Hill Notation): C₁₆H₁₄F₃N₃O₂S
• CAS Number: 103577-45-3
• Molecular Weight: 369.36
• MDL number: MFCD00866873
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to BP 872; traceable to Ph. Eur. Y0000773; traceable to USP 1356916
• API family: lansoprazole
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F
• InChI: 1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
• InChI key: MJIHNNLFOKEZEW-UHFFFAOYSA-N
• Gene Information: human ... ATP4A(495) , ATP4B(496)

Description

General description

Lansoprazole is an important proton pump inhibitor and a substituted benzimidazole with antisecretory and antiulcer activities. Its mode of action involves the suppression of gastric acid secretion by specific inhibition of the gastric H⁺/K⁺ ATPase enzyme system at the secretory surface of the gastric parietal cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Lansoprazole may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique, kinetic spectrophotometric technique and capillary electrophoresis.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3483 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable