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Key Documents

5.05145

Sigma-Aldrich

(+)-Tubocurarine Chloride

Synonym(s):

(+)-Tubocurarine Chloride, Nicotinic Acetylcholine Receptor Antagonist, (+)-Tubocurarine chloride, D-tubocurarine, DTC

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About This Item

Empirical Formula (Hill Notation):
C37H42Cl2N2O6
CAS Number:
Molecular Weight:
681.65
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

H2O: soluble

storage temp.

−20°C

InChI

1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1

InChI key

GXFZCDMWGMFGFL-KKXMJGKMSA-N

General description

A potent competitive antagonist of nAChR (IC50= 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.
A potent competitive antagonist of nAChR (IC50 = 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.

Biochem/physiol Actions

Primary Target
nAch

Warning

Toxicity: Toxic (F)

Preparation Note

Warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bowman, C., 2006. Br. J. Pharmacol.147, S277.
Wenningmann, I., et al. 2001. Mol. Pharmacol.60, 790.
Pederson, X., 1990. Proc. Natl. Acad. Sci. USA.87, 2785.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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