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Sigma-Aldrich

MnTBAP

≥95% (TLC), solid, SOD mimetic, Calbiochem®

Synonym(s):

MnTBAP, Mn(III)tetrakis(4-benzoic acid)porphyrin Chloride

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About This Item

Empirical Formula (Hill Notation):
C48H28ClMnN4O8
CAS Number:
Molecular Weight:
879.15
UNSPSC Code:
12352200
NACRES:
NA.77

product name

MnTBAP, Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.

Quality Level

Assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

brown

solubility

aqueous base: soluble

shipped in

ambient

storage temp.

−20°C

General description

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).

Biochem/physiol Actions

Cell permeable: yes
EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)
Primary Target
Superoxide dismutase (SOD) mimetic
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B J Day et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1227-1232 (1995-12-01)
There is an increased interest in development of therapeutic agents to treat disease states that involve reactive oxygen species in their pathophysiology. The metalloporphyrins, MnTBAP and ZnTBAP, were found to be active in a superoxide dismutase (SOD) assay. The efficacy
K M Faulkner et al.
The Journal of biological chemistry, 269(38), 23471-23476 (1994-09-23)
Several manganic porphyrins, with substituents on the methine bridge carbons, were prepared and examined for stability, redox behavior, catalysis of the dismutation of superoxide radical (O2-), and the ability to protect a superoxide dismutase (SOD)-null strain of E. coli against
M A Aladag et al.
Acta neurochirurgica, 145(8), 673-677 (2003-10-02)
Delayed cerebral vasoconstriction and brain ischemia, are critical problems in the management of a patient affected by rupture of an intracranial aneurysm. Overexpression of Cu-Zn superoxide dismutase (Cu-Zn SOD) can reduce the extent of cerebral vasospasm. We, therefore investigated if
C Szabó et al.
FEBS letters, 381(1-2), 82-86 (1996-02-26)
Here we report that the cell-permeable superoxide dismutase mimetic Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP) inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO). MnTBAP protects against the suppression of mitochondrial respiration in J774 cells exposed
Maria Catalina Gomez-Puerto et al.
International journal of molecular sciences, 21(11) (2020-06-14)
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by obstructed pulmonary vasculatures. Current therapies for PAH are limited and only alleviate symptoms. Reduced levels of BMPR2 are associated with PAH pathophysiology. Moreover, reactive oxygen species, inflammation and autophagy have

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