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H6377

Sigma-Aldrich

1-Hydroxypyridine-2-thione zinc salt

≥95%

Synonym(s):

Mercaptopyridine N-oxide zinc salt, Pyrithione

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About This Item

Empirical Formula (Hill Notation):
C10H8N2O2S2Zn
CAS Number:
13463-41-7
Molecular Weight:
317.70
EC Number:
236-671-3
MDL number:
MFCD00067336
UNSPSC Code:
12352100
PubChem Substance ID:
57654263
NACRES:
NA.22

Quality Level

100

Assay

≥95%

SMILES string

O1N2C=CC=CC2=[S][Zn]13ON4C=CC=CC4=[S]3

InChI

1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2

InChI key

OTPSWLRZXRHDNX-UHFFFAOYSA-L

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Application


  • Antimicrobial nanocoatings: The compound 1-Hydroxypyridine-2-thione zinc salt was evaluated for its efficacy in antimicrobial nanocoatings, showcasing its role in enhancing the performance of such coatings used in healthcare and industrial environments to prevent microbial contamination (Molling et al., 2014).

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - STOT RE 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Viswanath Kasi et al.
Biochemical and biophysical research communications, 410(2), 270-275 (2011-06-10)
Zinc pyrithione (ZPT), has a strong anti-apoptotic effect when administered just before reperfusion. Because oxidative stress has been proposed to contribute to myocardial reperfusion injury, we tested whether ZPT can reduce the production of reactive oxygen species during reoxygenation in
Kathy Kerr et al.
International journal of dermatology, 50(1), 102-113 (2010-12-25)
Dandruff is a common scalp condition characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect underlying histopathologic and biochemical events that must be reversed if treatment is to be effective. This study aimed to better characterize the state
Nancy L Reeder et al.
Antimicrobial agents and chemotherapy, 55(12), 5753-5760 (2011-09-29)
Zinc pyrithione (ZPT) is an antimicrobial material with widespread use in antidandruff shampoos and antifouling paints. Despite decades of commercial use, there is little understanding of its antimicrobial mechanism of action. We used a combination of genome-wide approaches (yeast deletion
N L Reeder et al.
The British journal of dermatology, 165 Suppl 2, 9-12 (2011-09-23)
Zinc pyrithione (ZPT) is the active ingredient most commonly used in many antidandruff treatments. Despite decades of successful use to treat human scalps, little is understood about the antifungal mechanism of action of ZPT. The objective of this study is
Marco Marcheselli et al.
Aquatic toxicology (Amsterdam, Netherlands), 102(1-2), 39-47 (2011-03-05)
The anti-fouling biocide zinc pyrithione (ZnPT) was recently demonstrated to be more persistent than expected in the coastal environment, and to have a potential for bioaccumulation. We investigated the occurrence of adverse effects in the marine mussel Mytilus galloprovincialis when
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