75666

5-(Benzylthio)-1H-tetrazole

≥99.0% (HPLC)

• Synonym(s): 5-Benzylmercapto-1,2,3,4-tetrazole, 5-Benzylmercaptotetrazole, 5-Benzylthio-1H-tetrazole, 5-[(Phenylmethyl)thio]-2H-tetrazole
• Empirical Formula (Hill Notation): C₈H₈N₄S
• CAS Number: 21871-47-6
• Molecular Weight: 192.24
• MDL number: MFCD00068731
• UNSPSC Code: 12352100
• PubChem Substance ID: 57652580
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥99.0% (HPLC)
• form: crystals
• mp: 135-138 °C (DSC-onset)
• SMILES string: C(Sc1nnn[nH]1)c2ccccc2
• InChI: 1S/C8H8N4S/c1-2-4-7(5-3-1)6-13-8-9-11-12-10-8/h1-5H,6H2,(H,9,10,11,12)
• InChI key: GXGKKIPUFAHZIZ-UHFFFAOYSA-N

Description

General description

5-(Benzylthio)-1H-tetrazole (BTT activator) is an organic compound that is used as an activator in the synthesis of oligonucleotides. The activator reacts with the phosphoramidite group to form a highly reactive intermediate. The intermediate then forms an internucleotide bond with the detritylated 5′-hydroxyl group of the growing oligonucleotide chain.

Other Notes

Activator for DNA synthesis; superior alternative to tetrazole

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves