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Sigma-Aldrich

Diethyl chloromalonate

95%

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About This Item

Linear Formula:
ClCH(CO2C2H5)2
CAS Number:
14064-10-9
Molecular Weight:
194.61
EC Number:
237-913-0
MDL number:
MFCD00009140
UNSPSC Code:
12352100
PubChem Substance ID:
24867397
NACRES:
NA.22

Quality Level

100

Assay

95%

form

liquid

refractive index

n20/D 1.432 (lit.)

density

1.204 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)C(Cl)C(=O)OCC

InChI

1S/C7H11ClO4/c1-3-11-6(9)5(8)7(10)12-4-2/h5H,3-4H2,1-2H3

InChI key

WLWCQKMQYZFTDR-UHFFFAOYSA-N

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General description

Diethyl chloromalonate (Diethyl α-chloromalonate) is a 2-halo-1,3-dicarbonyl compound. It participates in K2CO3-catalyzed domino reactions (Michael alkylation, Mannich alkylation, and aldol alkylation) of salicylic aldehyde derivatives to afford functionalized 2,3-dihydrobenzofurans. It reacts with Cs2CO3 in the presence of elemental S8 or Sen to afford the corresponding diethyl thioxo- or selenoxomalonates, which can be trapped in situ with various 1,3-dienes.

Signal Word

Danger

Hazard Statements

H314,H335,H400

Hazard Classifications

Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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R N Henrie et al.
Journal of medicinal chemistry, 26(4), 559-563 (1983-04-01)
Reaction of diethyl chloromalonate with beta-mercapto amines, 9, gave 1,4-thiazin-3-ones, 10, which were alkylated exclusively at the lactam oxygen with triethyloxonium tetrafluoroborate and subsequently condensed with guanidine to give the first reported 5-thiapterins, 8. Oxidation of 8 with m-chloroperoxybenzoic acid
Preparation of cycloaddition chemistry of thio-and selenocarbonyls derived from reaction of elemental sulfur and selenium with stabilized a-halo anions.
Abelman MM.
Tetrahedron Letters, 32(50), 7389-7392 (1990)
Qu-Bo Li et al.
The Journal of organic chemistry, 76(17), 7222-7228 (2011-07-29)
The K(2)CO(3)-catalyzed domino reactions (Michael alkylation, Mannich alkylation, and aldol alkylation) of salicylic aldehyde derivatives (2-hydroxyaryl-α,β-unsaturated ketones, 2-hydroxyarylnitroalkenes, 2-hydroxyarylimines, and salicylic aldehydes) and 2-halo-1,3-dicarbonyl compounds (diethyl α-bromomalonate, diethyl α-chloromalonate, ethyl 2-chloroacetoacetate, and 3-chloropentane-2,4-dione) were carried out under mild conditions to

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