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262099

Sigma-Aldrich

Phosphorus(V) oxychloride

99.999%

Synonym(s):

Phosphorus(V) oxide chloride, Phosphoryl chloride

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About This Item

Linear Formula:
POCl3
CAS Number:
10025-87-3
Molecular Weight:
153.33
EC Number:
233-046-7
MDL number:
MFCD00011443
UNSPSC Code:
12352101
PubChem Substance ID:
24855857
NACRES:
NA.22

vapor density

5.3 (vs air)

vapor pressure

104 mmHg ( 50 °C)
28 mmHg ( 20 °C)

Assay

99.999%

form

liquid

pH

1 (20 °C)

bp

105.8 °C (lit.)

mp

1.25 °C (lit.)

density

1.645 g/mL at 25 °C (lit.)

SMILES string

ClP(Cl)(Cl)=O

InChI

1S/Cl3OP/c1-5(2,3)4

InChI key

XHXFXVLFKHQFAL-UHFFFAOYSA-N

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Application

Phosphorus(V) oxychloride can be used as:
  • A dehydrating agent in organic synthesis.
  • A reagent in the cyclization of substituted aryl amides by Bischler−Napieralski cyclization reaction.
  • A precursor for phosphorus diffusion in the p-type silicon solar cells processing.

It can also be used in the Vilsmeier-Haack reaction to synthesize aromatic aldehydes.

accessory

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H302,H314,H330,H372

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1A - STOT RE 1 Inhalation

Target Organs

Respiratory Tract

Supplementary Hazards

EUH014,EUH029

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type Ru (II) complex-a parametric study
Pechavcek J, et al.
Tetrahedron Asymmetry, 24(4), 233-239 (2013)
Isocyanide 2.0
Patil P, et al.
Green Chemistry, 22(20), 6902-6911 (2020)
Optimization of phosphorus emitter formation from POCl 3 diffusion for p-type silicon solar cells processing
Ghembaza H, et al.
Silicon, 10(2), 377-386 (2018)
Rapid one-pot radiosynthesis of [carbonyl-. sup. 11C] formamides from primary amines and [. sup. 11C] CO. sub. 2.
Luzi Federico, et al.
EJNMMI radiopharmacy and chemistry, 5(1), 377-386 (2020)
Xiaohu Deng et al.
The Journal of organic chemistry, 76(20), 8262-8269 (2011-09-09)
A POCl(3)-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional group compatibility because of the metal-free, acidic reaction conditions. The yields
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