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SML0488

Sigma-Aldrich

Dobesilate Calcium

≥98% (HPLC)

Synonym(s):

2,5-Dihydroxybenzenesulfonic acid calcium salt, 205E, Calcium 2,5-dihydroxybenzenesulfonate, Calcium Dobesilate, Hydroquinone calcium sulfonate

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About This Item

Empirical Formula (Hill Notation):
C6H5O5S · 0.5Ca
CAS Number:
20123-80-2
Molecular Weight:
209.20
MDL number:
MFCD00867249
UNSPSC Code:
12352200
PubChem Substance ID:
329825438
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

room temp

SMILES string

[Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O

InChI

1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2

InChI key

QGNBTYAQAPLTMX-UHFFFAOYSA-L

General description

Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.

Application

Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.

Biochem/physiol Actions

Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Therapeutic effects of calcium dobesilate on diabetic nephropathy mediated through reduction of expression of PAI?1.
Zhang X
Experimental and Therapeutic Medicine, 5(1), 295-299 (2013)
Jaimi A Gray et al.
BMC evolutionary biology, 19(1), 7-7 (2019-01-10)
Morphological diversity among closely related animals can be the result of differing growth patterns. The Australian radiation of agamid lizards (Amphibolurinae) exhibits great ecological and morphological diversity, which they have achieved on a continent-wide scale, in a relatively short period
Xiuzhi Guo et al.
Clinica chimica acta; international journal of clinical chemistry, 483, 1-5 (2018-04-14)
We reported that calcium dobesilate, a vasoprotective agent mainly used for diabetic retinopathy (DR), negatively interferes with glycated albumin (GA) assays involving enzymatic methods. A calcium dobesilate standard was added to 3serum pools in vitro to prepare concentration-response series according
Negative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays.
Guo X, et al.
PLoS ONE, 13(2), e0192440-e0192440 (2018)
Varut Lohsiriwat
World journal of gastroenterology, 18(17), 2009-2017 (2012-05-09)
This review discusses the pathophysiology, epidemiology, risk factors, classification, clinical evaluation, and current non-operative and operative treatment of hemorrhoids. Hemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions. The most common symptom of hemorrhoids
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