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SCP0111

Sigma-Aldrich

Cell Adhesion Inhibitor Peptide

≥95% (HPLC), lyophilized powder, cyclic

Synonym(s):

cyloRGDfV

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About This Item

Empirical Formula (Hill Notation):
C26H38N8O7
Molecular Weight:
574.63
UNSPSC Code:
12352202
NACRES:
NA.32

product name

Cell Adhesion Inhibitor Peptide, cyclic,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Arg-Gly-Asp-Phe-Val

Application

Cyclic RGDFV (cyloRGDfV) is an RGD containing peptide antagonist, with specificity for α(V)β(3) integrin, that is used to inhibit the binding of cells to RGD proteins such as vitronectin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Warren B Nothnick et al.
PloS one, 9(6), e100336-e100336 (2014-06-18)
Endometriosis is defined as the growth of endometrial glandular and stromal components in ectopic locations and affects as many as 10% of all women of reproductive age. Despite its high prevalence, the pathogenesis of endometriosis remains poorly understood. MicroRNAs, small
Damien Garbett et al.
Nature communications, 11(1), 4818-4818 (2020-09-25)
Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relatively weak as single filaments, must polymerize outward from adhesion
Joel D Pearson et al.
Cancer cell, 39(8), 1115-1134 (2021-07-17)
Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching rules that supersede variability. Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies

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