SAB4300738

Anti-Collagen IV antibody produced in rabbit

affinity isolated antibody

• Synonym(s): ALPHA-1 CHAIN ARRESTEN, COL4A1 NC1 domain, COLLAGEN OF BASEMENT MEMBRANE, alpha 1 type IV collagen preproprotein, collagen IV alpha-1 polypeptide
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 160 kDa
• species reactivity: mouse, human
• concentration: 1.0 mg/mL
• technique(s): immunohistochemistry: 1:50-1:100; western blot: 1:500-1:3000 (Cell Lysate)
• isotype: IgG
• accession no.: NP_001836.2
• UniProt accession no.: P02462
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... COL4A1(1282)

Description

General description

COL4A1 (collagen type IV α 1 chain) belongs to the collagen family. It has an N-terminal 7S domain, a C-terminal globular domain (NC1), and the central triple helical part with short interruptions of the Gly-X-Y repeats. It is an important constituent of type IV collagen in the basement membrane. The COL4A1 gene is located on human chromosome 13q34.

Specificity

The antibody detects endogenous levels of total Collagen IV protein.

Immunogen

Synthesized peptide derived from human Collagen IV.

Application

Collagen Type IV from human cell culture has been used in immunofluorescent analysis.

Biochem/physiol Actions

COL4A1 (collagen type IV α 1 chain) related disorder is associated with pulmonary complication. Mutations in COL4A1 result in familial porencephaly, infantile hemiplegia, cerebral small vessel disease (CSVD) and hemorrhagic stroke.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable