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L5044

Sigma-Aldrich

Anti-LXRα (N-terminal) antibody produced in rabbit

enhanced validation

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-LX receptor, alpha, Anti-LXR-a, Anti-LXRA, Anti-Liver X receptor a, Anti-NR1H3, nuclear receptor subfamily 1 group H, member 3, Anti-RLD-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 1-2 μg/mL using HEK-293T cells expressing human LXRα

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NR1H3(10062)
mouse ... Nr1h3(22259)
rat ... Nr1h3(58852)

General description

The gene LXR α (liver X receptor α) is a member of LXRs that belong to the nuclear receptor superfamily. The encoded protein is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The gene is mapped to human chromosome 11p11.2. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity.
The liver X receptors (LXRs) are encoded by two different genes, LXRα (NR1H3) and LXRβ (NR1H2). LXRα expression is restricted to macrophages and tissues involved in lipid metabolism.

Application

Anti-LXRα (N-terminal) antibody produced in rabbit has also been used for western blotting.
Anti-LXRα (N-terminal) antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions

Liver X receptors (LXRs) heterodimerize with the retinoid X receptor (RXR) and bind to the LXR response element (LXRE). LXRs regulate cholesterol homeostasis by modulating the transcription of genes involved in its catabolism, storage, absorption and transport. Activated LXRs are also potent inhibitors of inflammatory responses in macrophages and reduce inflammation in vivo. LXR expression and activation with LXRs ligands have also been shown to modulate atherosclerotic lesions. LXRα/β-deficient mice show enhanced lipid-loaded foam cell accumulation. LXRs have been suggested to play an important role in Alzheimer′s disease (AD) pathogenesis.
The gene LXR α (liver X receptor α) encodes a protein that plays an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification of macrophage liver X receptors as inhibitors of atherosclerosis
Tangirala RK, et al.
Proceedings of the National Academy of Sciences of the USA, 99(18), 11896-11901 (2002)
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
Zelcer N, et al.
Proceedings of the National Academy of Sciences of the USA, 104(25), 10601-10606 (2007)
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
Joseph SB, et al.
Nature Medicine, 9(2), 213-213 (2003)
Liver X receptors as integrators of metabolic and inflammatory signaling
Zelcer N and Tontonoz P
The Journal of Clinical Investigation, 116(3), 607-614 (2006)
Gang Wang et al.
Cell death & disease, 12(3), 254-254 (2021-03-12)
C1q tumor necrosis factor-related protein 12 (CTRP12), a conserved paralog of adiponectin, is closely associated with cardiovascular disease. However, little is known about its role in atherogenesis. The aim of this study was to examine the influence of CTRP12 on

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