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H5534

Sigma-Aldrich

trans-4-Hydroxy-L-proline

≥98.5%, suitable for cell culture, BioReagent

Synonym(s):

4-Hydroxyproline, Hydroxyproline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp

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About This Item

Empirical Formula (Hill Notation):
C5H9NO3
CAS Number:
51-35-4
Molecular Weight:
131.13
Beilstein:
81441
EC Number:
200-091-9
MDL number:
MFCD00064320
UNSPSC Code:
12352209
PubChem Substance ID:
24895700
NACRES:
NA.26

product name

trans-4-Hydroxy-L-proline, BioReagent, suitable for cell culture, ≥98.5%

product line

BioReagent

Assay

≥98.5%

form

crystalline

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless

mp

273 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

application(s)

peptide synthesis

SMILES string

O[C@H]1CN[C@@H](C1)C(O)=O

InChI

1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

InChI key

PMMYEEVYMWASQN-DMTCNVIQSA-N

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Related Categories

Application


  • Cysteine Radical and Glutamate Collaboratively Enable C-H Bond Activation and C-N Bond Cleavage in a Glycyl Radical Enzyme HplG.: This research showcases the application of trans-4-hydroxy-L-proline in studying enzymatic reactions that involve C-H bond activation and C-N bond cleavage, providing insights into the mechanisms of enzymatic control and specificity which are essential for the development of novel biochemical processes (Deng and Liao, 2024).

  • Study on flavor quality formation in green and yellow tea processing by means of UPLC-MS approach.: Utilizing trans-4-hydroxy-L-proline, this study enhances the understanding of flavor biochemistry in tea processing, offering significant insights into the food chemistry sector and influencing future product development strategies (Sun et al., 2024).


Other Notes

Natural constituent of animal structural proteins such as collagen and elastin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Proline and hydroxyproline metabolism: implications for animal and human nutrition
Guoyao Wu
Amino Acids, 40{4}, 1053-1063 (2011)
Biochemical Markers of Bone Turnover Part I: Biochemistry and Variability
Biochemical Markers of Bone Turnover Part I: Markus J Markus J Seibel
The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists, 26(4), 97-122 (2005)
Effect of Function-Enhanced Mesenchymal Stem Cells Infected With Decorin-Expressing Adenovirus on Hepatic Fibrosis
Jang Yoon O
Stem Cells Translational Medicine, 5, 1247-1256 (2016)
Carcass traits and M. longissimus lumborum palatability attributes of calf- and yearling-finished steers.
P. S. Brewer
Journal of Animal Science, 85(5), 1239-1246 (2007)
Aastha Arora et al.
Frontiers in pharmacology, 9, 394-394 (2018-05-10)
Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising of pneumonitis and fibrosis, poses challenge in its use as a front-line chemotherapeutic. Although Amifostine has been found to protect
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