G1377
Gly-Gly-Gly
≥98% (TLC)
Synonym(s):
Glycyl-glycyl-glycine, Triglycine
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About This Item
Linear Formula:
NH2CH2CONHCH2CONHCH2COOH
CAS Number:
Molecular Weight:
189.17
Beilstein:
1711130
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
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Product Name
Gly-Gly-Gly,
Assay
≥98% (TLC)
Quality Level
form
powder
color
white
application(s)
peptide synthesis
SMILES string
NCC(=O)NCC(=O)NCC(O)=O
InChI
1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)
InChI key
XKUKSGPZAADMRA-UHFFFAOYSA-N
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Amino Acid Sequence
Gly-Gly-Gly
Application
Triglycine (Gly-Gly-Gly) is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. Triglycine is used as a copper chelator.
Biochem/physiol Actions
Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Blake E Ziegler et al.
The journal of physical chemistry. A, 114(44), 11953-11963 (2010-10-26)
Hydrogen/deuterium exchange reactions involving protonated triglycine and deuterated ammonia (ND(3)) have been examined in the gas phase using a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. Ab initio and density functional theory (DFT) calculations have been carried out to
S J Woltman et al.
Analytical chemistry, 67(3), 541-551 (1995-02-01)
The reversible electrochemistry of the Cu(II)/Cu(III) couple was investigated for the copper(II) complexes of triglycine (G3), tetraglycine (G4), and pentaglycine (G5) in alkaline solution using a rotating ring-disk electrode (RRDE). The study was motivated by the need to elucidate electrochemical
Investigation of protein conformation and interactions with salts via X-ray absorption spectroscopy.
Craig P Schwartz et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(32), 14008-14013 (2010-07-28)
Nitrogen K-edge spectra of aqueous triglycine were measured using liquid microjets, and the effects of Hofmeister-active salts on the spectra were observed. Spectra simulated using density functional theory, sampled from room temperature classical molecular dynamics trajectories, capture all major features
Avisek Chatterjee et al.
The Journal of chemical physics, 129(10), 105104-105104 (2008-12-03)
X-ray photoelectron spectroscopy (XPS) has been used to investigate the core-level electronic structures of glycine (G) and its peptides, including glycyl-glycine (GG), diglycyl-glycine (GGG), and polyglycine (poly-G), in their powder forms. Increasing the number of G units in the peptides
Sudipta Chakraborty et al.
Bioconjugate chemistry, 21(5), 969-978 (2010-04-15)
This report presents the synthesis and evaluation of (111)In(DOTA-6G-RGD(4)) (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid; 6G-RGD(4) = E{G(3)-E[G(3)-c(RGDfK)](2)}(2) and G(3) = Gly-Gly-Gly), (111)In(DOTA-RGD(4)) (RGD(4) = E{E[c(RGDfK)](2)}(2)) and (111)In(DOTA-3G-RGD(2)) (3G-RGD(2) = G(3)-E[G(3)-c(RGDfK)](2)) as new radiotracers for imaging integrin alpha(v)beta(3)-positive tumors. The IC(50) values
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