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Y0000108

Trihexyphenidyl hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H31NO · HCl
CAS Number:
52-49-3
Molecular Weight:
337.93
MDL number:
MFCD00058212
UNSPSC Code:
41116107
PubChem Substance ID:
329830848
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

trihexyphenidyl hydrochloride

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3

InChI

1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H

InChI key

QDWJJTJNXAKQKD-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Trihexyphenidyl hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Fa yi xue za zhi, 27(4), 271-273 (2011-09-15)
To develop a method to measure trihexyphenidyl, chlorpromazine and clozapine in human blood with GC-MS. The specimens were alkalized (pH > 10) and extracted with V (benzene):V(ethyl acetate) = 1:1, and qualitatively analyzed using GC-MS-Full Scan with internal standard SKF525A.
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Journal of child neurology, 26(7), 810-816 (2011-04-19)
There are conflicting reports regarding the efficacy of trihexyphenidyl, an anticholinergic drug, for treatment of dystonia in cerebral palsy. The author hypothesized that trihexyphenidyl may be more effective in specific subgroups and performed a retrospective analysis of 31 children (8.2
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We studied the effect of anti-cholinergic therapy on axial symptoms that show a tendency to worsen over time after deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson's disease (PD). We conducted a prospective study of 20
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