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15307

Sigma-Aldrich

Chloral hydrate

≥99%

Synonym(s):

Trichloroacetaldehyde hydrate

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About This Item

Linear Formula:
Cl3CCH(OH)2
CAS Number:
302-17-0
Molecular Weight:
165.40
Beilstein:
1698497
EC Number:
206-117-5
MDL number:
MFCD00044479
UNSPSC Code:
12352100
PubChem Substance ID:
57647358
NACRES:
NA.22

Quality Level

100

Assay

≥99%

reaction suitability

reagent type: cross-linking reagent

drug control

USDEA Schedule IV

impurities

chlor alcoholate, complies
 organic volatile impurities, complies (GC)
 residual solvents Toluene, Chloroform, Benzene, complies
≤0.002% heavy metals (as Pb)
≤0.1% non-volatile matter

ign. residue

≤0.1% (as SO4)

pH

2.8-5.5 (20 °C, 10%)

mp

57 °C (lit.)

anion traces

chloride (Cl-): ≤70 mg/kg

suitability

complies for appearance of solution
complies for reaction against H2SO4

SMILES string

OC(O)C(Cl)(Cl)Cl

InChI

1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H

InChI key

RNFNDJAIBTYOQL-UHFFFAOYSA-N

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Application

Chloral hydrate is used in many protocols as a clearing agent for the microscopic examination of plant tissues without disrupting the cellular features.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL5133
BCCM1489
BCCL5134
BCCL1533
BCCK7192

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Analyses of plant leaf cell size, density and number, as well as trichome number using cell counter plugin.
Cheng Y, et al.
Bio-protocol, 4(13) (2014)
An improved clearing and mounting solution to replace chloral hydrate in microscopic applications.
Villani T S
Applications in plant sciences, 1(5), 1300016-1300016 (2013)
Cytohistological Analyses of Mega-sporogenesis and Gametogenesis in Ovules of Limonium spp.
Rois A S and Caperta A D
Bio-protocol, 6(21) (2016)
Simone Jürschik et al.
Journal of mass spectrometry : JMS, 47(9), 1092-1097 (2012-09-14)
In this work, we illustrate the application of proton transfer reaction mass spectrometry (PTR-MS) in the field of food and drink safety. We present proof-of-principle measurements of four different drinks (water, tea, red wine and white wine) each spiked separately
S R Graham et al.
The Medical journal of Australia, 149(11-12), 686-688 (1988-12-05)
The purpose of this review is to highlight the toxicity of chloral hydrate and to review the management of overdoses with chloral hydrate. Three patients are presented in whom life-threatening cardiac arrhythmias dominated the clinical presentation. These arrhythmias were resistant
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