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T45802

Sigma-Aldrich

2,4,6-Triaminopyrimidine

97%

Synonym(s):

2,4,6-Pyrimidinetriamine

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About This Item

Empirical Formula (Hill Notation):
C4H7N5
CAS Number:
1004-38-2
Molecular Weight:
125.13
Beilstein:
118448
EC Number:
213-720-7
MDL number:
MFCD00006100
UNSPSC Code:
12352100
PubChem Substance ID:
24900218
NACRES:
NA.22

Assay

97%

mp

249-251 °C (lit.)

SMILES string

Nc1cc(N)nc(N)n1

InChI

1S/C4H7N5/c5-2-1-3(6)9-4(7)8-2/h1H,(H6,5,6,7,8,9)

InChI key

JTTIOYHBNXDJOD-UHFFFAOYSA-N

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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W L Armarego et al.
The Biochemical journal, 211(2), 357-361 (1983-05-01)
The Km and kcat. values for [6,6,7,7-2H]7,8(6H)-dihydropterin and 2,6-diamino-5-iminopyrimidin-4-one were determined for dihydropteridine reductase (EC 1.6.99.10) from two sources. The parameters of the pterin are of the same order as those of the most effective substrates of dihydropteridine reductase. The
M P Vinardell et al.
Revista espanola de fisiologia, 39(2), 193-196 (1983-06-01)
D-glucose diffusion in both jejunum and ileum using a perfusion system in vivo was determined. 2,4,6-triaminopyrimidine (20 mM) induced an inhibition on D-glucose diffusion of 32% in the two segments of the small intestine studied. Glucose net efflux from the
S D Provan et al.
The Journal of pharmacology and experimental therapeutics, 245(3), 928-931 (1988-06-01)
An in situ rat gut preparation was used to elucidate the mechanisms of gastrointestinal aluminum (Al) absorption. Al uptake rate at the mucosal surface was decreased by the paracellular pathway blockers kinetin (1 mM) and 2,4,6-triaminopyrimidinium (10 mM), by sodium
R Soni et al.
Journal of the National Cancer Institute, 93(6), 436-446 (2001-03-22)
Cyclin-dependent kinase 4 (Cdk4) represents a prime target for the treatment of cancer because most human cancers are characterized by overexpression of its activating partner cyclin D1, loss of the natural Cdk4-specific inhibitor p16, or mutation(s) in Cdk4's catalytic subunit.
J W Jansen et al.
Biochimica et biophysica acta, 598(1), 115-126 (1980-05-08)
1. The permeability of the paracellular pathway in the isolated rabbit pancreas has been studied with the aid of 2,4,6-triaminopyrimidine. 2. Addition of 2,4,6-triaminopyrimidine (1--10 mM) to the bathing medium has no effect on the rate of fluid secretion or
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