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Hepatocyte Growth Factor (HGF)

Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis. HGF is the ligand for a receptor encoded by the c-met proto-oncogene. c-Met expression has been observed in tumors from many sources, including stomach, lung, breast, kidney colon, liver, and melanoma, and is associated with tumor progression and metastasis.

Hepatocyte Growth Factor (HGF)

Product DescriptionSourceRecombinant HostPhysical FormAssayCell Type AffectedProduct No.
Hepatocyte Growth FactorhumanBaculovirus infected High-5 cellslyophilized powderThe biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the HGF responsive monkey epithelial cell line, 4MBr-5.renal tubular epithelial cell hepatocyte epidermal keratinocyte epidermal keratinocyteH1404
Hepatocyte Growth Factorhumanmouse NSO cellslyophilized powderThe biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the HGF responsive monkey epithelial cell line, 4MBr-5.hepatocyte epidermal keratinocyte renal tubular epithelial cell epidermal melanocyteH9661
Materials
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References

1.
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. 2003. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 4(12):915-925. https://doi.org/10.1038/nrm1261
2.
Ma PC. 2003. 22(4):309-325. https://doi.org/10.1023/a:1023768811842
3.
Zhang Y, Vande Woude GF. 2003. HGF/SF-met signaling in the control of branching morphogenesis and invasion. J. Cell. Biochem.. 88(2):408-417. https://doi.org/10.1002/jcb.10358
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