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Key Documents

SML2235

Sigma-Aldrich

CL075

≥98% (HPLC)

Synonym(s):

2-Propylthiazolo[4,5-c]quinolin-4-amine, 3M002

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About This Item

Empirical Formula (Hill Notation):
C13H13N3S
CAS Number:
Molecular Weight:
243.33
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)

InChI key

NFYMGJSUKCDVJR-UHFFFAOYSA-N

Application

CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.

Biochem/physiol Actions

CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFΚB stimulation in TLR8 compared to 4 μM for TLR7.
CL075 is a thiazoloquinolone derivative. It might influence tumor development.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cytotoxic activity of human dendritic cells induces RIPK1-dependent cell death
Varga Z, et al.
Immunobiology, 152032-152032 (2020)
Marianne W Mureith et al.
AIDS (London, England), 24(12), 1841-1848 (2010-07-01)
Chronic HIV-1 infection is characterized by high levels of persistent immune activation. Both HIV-1-encoded Toll-like receptor 7/8 (TLR7/8) ligands and TLR ligands encoded by products of microbial translocation have been implicated in inducing and sustaining immune activation in infected individuals
Heng Yang et al.
Zhonghua zhong liu za zhi [Chinese journal of oncology], 33(9), 643-648 (2012-02-22)
To observe the expression of Toll-like receptor 8 (TLR8) in human cervical cancer cell-line HeLa cells, and the effects of TLR8 agonist CL075 on the survival and proliferation of HeLa cells. PCR and RT-PCR were used to detect the expression

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