Manufacturing information is considered proprietary and is not disclosed. Product H0654 is not prepared from Product H3274. The specific Hygromycin B used in the preparation of the solution is not identified.
H0654
Hygromycin B solution from Streptomyces hygroscopicus
≥60% (HPLC), 45-60 mg/mL in H2O
Synonym(s):
Hygromycin B, Hygrovetine
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About This Item
Empirical Formula (Hill Notation):
C20H37N3O13
CAS Number:
Molecular Weight:
527.52
Beilstein:
6755837
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85
Pricing and availability is not currently available.
Recommended Products
biological source
Streptomyces hygroscopicus
Quality Level
sterility
0.22 μm filtered
concentration
≥60% (HPLC)
45-60 mg/mL in H2O
color
brown-yellow
light orange to dark orange
light yellow to dark yellow
antibiotic activity spectrum
viruses
Mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O
InChI
1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
InChI key
GRRNUXAQVGOGFE-XKIAHZFYSA-N
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General description
Chemical structure: aminoglycoside
Application
Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.
Biochem/physiol Actions
Mode of action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.
Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.
Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.
Caution
Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.
Preparation Note
This product is a solution that comes =60% (HPAE) and 45-60 mg/mL in H2O.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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