AB5511
Anti-Opioid Receptor Antibody, µ, pain
serum, Chemicon®
Synonym(s):
mu opiate receptor, opioid receptor, mu 1
Sign Into View Organizational & Contract Pricing
All Photos(4)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, primate, rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... OPRM1(4988)
General description
Opiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, δ, κ, and µ (also known as OP1, OP2 and OP3, respectively), that activate Gi/o to reduce intracellular cAMP levels. Although most clinically used opioids function by activation of the µ opioid receptor, agonists of spinal δ opioid receptors have antinociceptive activity that is independent of µ. In addition, activation of δ increases locomotor activity, inhibits gastrointestinal motility, and decreases respiratory frequency (Dhawan et al., 1996). Agonists for δ opioid receptors also exhibit antidepressant-like activity in animal models (Broom et al., 2002).
Specificity
Mu Opioid receptor.
Other species have not been tested.
Immunogen
Epitope: C-terminus
Synthetic peptide from the C-terminus of rat Mu Opioid receptor.
Application
Detect Opioid Receptor using this Anti-Opioid Receptor Antibody, µ, pain validated for use in IC, IH & WB.
Immunohistochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Western blot:
1:1,000 dilution of a previous lot was used.
Immunocytochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Optimal working dilutions must be determined by the end user.
1:2,500-1:5,000 dilution of a previous lot was used.
Western blot:
1:1,000 dilution of a previous lot was used.
Immunocytochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuroinflammation & Pain
Neuroinflammation & Pain
Quality
Evaluated by Western Blot on Human Liver lysate.
Western Blot Analysis:
1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate.
Western Blot Analysis:
1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate.
Target description
45 kDa
Physical form
Rabbit polyclonal serum in buffer containing 0.05% sodium azide.
Unpurified
Storage and Stability
Stable for 1 year at -20ºC from date of receipt.
Analysis Note
Control
Spinal cord, liver lysate
Spinal cord, liver lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Haizea Estomba et al.
PloS one, 11(3), e0152162-e0152162 (2016-04-01)
The presence of endogenous opioid peptides in different testicular cell types has been extensively characterized and provides evidence for the participation of the opioid system in the regulation of testicular function. However, the exact role of the opioid system during
Polina Kosillo et al.
eLife, 11 (2022-07-27)
The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology. mTOR exists in two distinct multiprotein complexes
Sophie K Billa et al.
The European journal of neuroscience, 32(4), 625-631 (2010-07-16)
The addictive properties of morphine limit its clinical use. Learned associations that develop between the abused opiate and the environment in which it is consumed are engendered through Pavlovian conditioning processes. Disruption of the learned associations between the opiate and
Dinesh V Raju et al.
The Journal of comparative neurology, 499(2), 231-243 (2006-09-16)
The striatum is divided into two compartments named the patch (or striosome) and the matrix. Although these two compartments can be differentiated by their neurochemical content or afferent and efferent projections, the synaptology of inputs to these striatal regions remains
Sex differences in ?-opioid receptor expression in trigeminal ganglia under a myositis condition in rats.
Zhang, X; Zhang, Y; Asgar, J; Niu, KY; Lee, J; Lee, KS; Schneider, M; Ro, JY
European Journal of Pain null
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service